INT303546

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fgfr2) Golgi apparatus (Fgfr2) plasma membrane (Fgfr2)
nucleus (Fgfr2) kinase activity (Fgfr2) cell-cell signaling (Fgfr2)
Fgfr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 10 65.20 Quite High
Inflammation 52 64.04 Quite High
cytokine 16 5.00 Very Low Very Low Very Low
member 8 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Abnormalities 4 91.84 High High
Injury 6 78.64 Quite High
Targeted Disruption 28 68.96 Quite High
Disease 2 67.92 Quite High
Psoriasis 14 67.72 Quite High
INFLAMMATION 58 64.84 Quite High
Frailty 2 60.56 Quite High
Congenital Anomalies 20 58.72 Quite High
Alopecia 6 56.48 Quite High
Acanthosis 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it binds a different set of FGFs than FGFR1IIIb and FGFR2IIIb (Zhang et al., 2006), which suggests distinct functions.
FGFR2IIIb Binding (binds) of
1) Confidence 0.46 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.28 Pain Relevance 0.03
For example, the IIIb splice variant of FGFR2 (FGFR2IIIb) is a high-affinity receptor for FGF7, FGF10, and FGF22, whereas the IIIc variant (FGFR2IIIc) binds a variety of other FGF ligands (Zhang et al., 2006).
FGFR2IIIc Binding (binds) of
2) Confidence 0.34 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.46 Pain Relevance 0.03

General Comments

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