INT30355

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Context Info
Confidence 0.67
First Reported 1985
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 23
Disease Relevance 14.61
Pain Relevance 4.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Anatomy Link Frequency
brain 14
microglia 6
neurons 4
uterine 2
Alox5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 294 99.76 Very High Very High Very High
cINOD 36 98.44 Very High Very High Very High
antagonist 14 97.60 Very High Very High Very High
Inflammatory mediators 56 95.44 Very High Very High Very High
agonist 4 95.00 High High
Potency 2 91.92 High High
Inflammation 314 89.28 High High
Inflammatory response 42 82.32 Quite High
Bioavailability 56 80.72 Quite High
metalloproteinase 1 68.88 Quite High
Disease Link Frequency Relevance Heat
Injury 311 99.98 Very High Very High Very High
Cv General 4 Under Development 42 99.76 Very High Very High Very High
Stroke 246 99.72 Very High Very High Very High
Middle Cerebral Artery Infarction 104 98.88 Very High Very High Very High
Disease 42 98.60 Very High Very High Very High
Infarction 112 96.12 Very High Very High Very High
INFLAMMATION 436 95.44 Very High Very High Very High
Ulcers 4 89.96 High High
Increased Venous Pressure Under Development 14 88.64 High High
Cv Unclassified Under Development 182 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rosiglitazone induced brain 5-lipoxygenase (5-LO) expression in ischemic rat brain, concomitantly with neuroprotection.
Positive_regulation (induced) of Gene_expression (expression) of 5-lipoxygenase in brain
1) Confidence 0.67 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19321784 Disease Relevance 0.70 Pain Relevance 0.20
At the lowest concentration tested (1 microgram ml-1), indomethacin markedly increased the accumulation of lipoxygenase products in the cell incubates.
Positive_regulation (accumulation) of Gene_expression (products) of lipoxygenase
2) Confidence 0.50 Published 1985 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2864427 Disease Relevance 0.17 Pain Relevance 0.21
Naproxen, ibuprofen or piroxicam 1 or 10 micrograms ml-1 resulted in smaller increases of lipoxygenase products, and there was only a small rise with these concentrations of isoxicam.
Positive_regulation (increases) of Gene_expression (products) of lipoxygenase
3) Confidence 0.50 Published 1985 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2864427 Disease Relevance 0.16 Pain Relevance 0.20
Synthesis of lipoxin A4 by 5-lipoxygenase mediates PPARgamma-dependent, neuroprotective effects of rosiglitazone in experimental stroke.
Positive_regulation (mediates) of Gene_expression (Synthesis) of 5-lipoxygenase associated with stroke
4) Confidence 0.49 Published 2009 Journal J. Neurosci. Section Title Doc Link 19321784 Disease Relevance 0.62 Pain Relevance 0.15
All of these results suggest that an overproduction of leukotrienes and other lipoxygenase products, following cyclooxygenase blockade induced by NSAIDs, may play a role in the development of gastric mucosal damage.
Positive_regulation (overproduction) of Gene_expression (products) of lipoxygenase associated with cinod
5) Confidence 0.41 Published 1993 Journal Arzneimittelforschung Section Abstract Doc Link 8369011 Disease Relevance 0.16 Pain Relevance 0.30
To investigate the hypothesis that the gastric damage caused by NSAIDs is due not only to the decreased level of cyclooxygenase products but to the increased level of lipoxygenase products as well, different lipoxygenase inhibitors and leukotriene antagonists were tested.
Positive_regulation (increased) of Gene_expression (products) of lipoxygenase associated with antagonist and cinod
6) Confidence 0.41 Published 1993 Journal Arzneimittelforschung Section Abstract Doc Link 8369011 Disease Relevance 0.22 Pain Relevance 0.36
Beside the decreased level of the so-called cytoprotective prostaglandins caused by the inhibition of cyclooxygenase enzyme an overproduction of 5-lipoxygenase products (leukotrienes) was also found.
Positive_regulation (overproduction) of Gene_expression (overproduction) of lipoxygenase
7) Confidence 0.36 Published 1993 Journal Arzneimittelforschung Section Abstract Doc Link 8369011 Disease Relevance 0.21 Pain Relevance 0.29
Beside the decreased level of the so-called cytoprotective prostaglandins caused by the inhibition of cyclooxygenase enzyme an overproduction of 5-lipoxygenase products (leukotrienes) was also found.
Positive_regulation (overproduction) of Gene_expression (products) of lipoxygenase
8) Confidence 0.36 Published 1993 Journal Arzneimittelforschung Section Abstract Doc Link 8369011 Disease Relevance 0.21 Pain Relevance 0.29
It is possible that an increase in the uterine expression of LO gene may be involved in this obstruction.
Positive_regulation (increase) of Gene_expression (expression) of LO gene in uterine
9) Confidence 0.24 Published 2004 Journal J. Endocrinol. Section Abstract Doc Link 14765986 Disease Relevance 0.21 Pain Relevance 0.09
Immunohistochemical study of brain sections showed IR-mediated increased expression of 5-LOX in the neurons and microglia.
Positive_regulation (mediated) of Gene_expression (expression) of 5-LOX in microglia
10) Confidence 0.23 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1526713 Disease Relevance 0.91 Pain Relevance 0.21
We demonstrated in this study that IR injury caused an increased expression of 5-LOX, NF-?
Positive_regulation (caused) of Gene_expression (expression) of 5-LOX associated with injury
11) Confidence 0.23 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 1.59 Pain Relevance 0.42
As in human brain following stroke [7], we found increased expression of 5-LOX after IR in rat brain neurons and microglia/macrophage (Fig. 2).
Positive_regulation (increased) of Gene_expression (expression) of 5-LOX in brain associated with stroke
12) Confidence 0.23 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.92 Pain Relevance 0.21
Immunohistochemical study of brain sections showed IR-mediated increased expression of 5-LOX in the neurons and microglia.
Positive_regulation (increased) of Gene_expression (expression) of 5-LOX in microglia
13) Confidence 0.23 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1526713 Disease Relevance 0.90 Pain Relevance 0.21
Co-localization of 5-LOX expression in neurons and microglia/macrophage in brain after IR injury.As inferred from the data above (Fig. 1E, a–c), there is an increase in the expression of 5-LOX enzyme after IR injury.
Positive_regulation (increase) of Gene_expression (expression) of 5-LOX in brain associated with injury
14) Confidence 0.23 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.52 Pain Relevance 0.06
We demonstrated in this study that IR injury caused an increased expression of 5-LOX, NF-?
Positive_regulation (increased) of Gene_expression (expression) of 5-LOX associated with injury
15) Confidence 0.23 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 1.59 Pain Relevance 0.41
To determine the cellular localization of 5-LOX expression, sections from ischemic brain after 24 h of reperfusion were subjected to immunohistochemistry with antibody against 5-LOX. 5-LOX expression co-localized with NSE, a neuron specific marker, implying that 5-LOX protein expression was increased in neurons after IR (Fig. 2c).
Positive_regulation (increased) of Gene_expression (expression) of 5-LOX protein in neurons
16) Confidence 0.23 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.30 Pain Relevance 0
As concluded from the data above (Figs. 1E and 2), there is an increased expression of 5-LOX enzyme in the brain after IR injury.
Positive_regulation (increased) of Gene_expression (expression) of 5-LOX in brain associated with injury
17) Confidence 0.16 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.65 Pain Relevance 0.09
Increased leukotriene levels and 5-LOX expression have been documented in stroke patients [7].
Positive_regulation (Increased) of Gene_expression (expression) of 5-LOX associated with stroke
18) Confidence 0.15 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 1.03 Pain Relevance 0.24
Postmortem studies have shown that brain sections from stroke patients are positive for 5-LOX expression [7].
Positive_regulation (positive) of Gene_expression (expression) of 5-LOX in brain associated with stroke
19) Confidence 0.15 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.57 Pain Relevance 0.12
To investigate the increased expression of the 5-LOX enzyme after IR injury, and whether administration of BW-B 70C reduces the 5-LOX expression, we subjected rat brain tissue sections to immunohistochemistry (Fig. 1E, a–c).
Spec (investigate) Positive_regulation (increased) of Spec (investigate) Gene_expression (expression) of 5-LOX in brain associated with injury
20) Confidence 0.15 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.57 Pain Relevance 0.12

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