INT303550

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.32
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Cldn1) plasma membrane (Cldn1)
Cldn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 26 90.48 High High
cytokine 8 12.12 Low Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 29 90.48 High High
Alopecia 3 89.12 High High
Targeted Disruption 14 76.80 Quite High
Aging 4 30.32 Quite Low
Congenital Anomalies 10 5.00 Very Low Very Low Very Low
Acanthosis 8 5.00 Very Low Very Low Very Low
Psoriasis 7 5.00 Very Low Very Low Very Low
Dermatitis 6 5.00 Very Low Very Low Very Low
Skin Diseases 5 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis of epidermal lysates confirmed the down-regulation of claudin 3 and occludin at the protein level and also revealed reduced claudin-1 expression in K5-R1/R2 mice (Fig. 8 C).
Negative_regulation (reduced) of Gene_expression (expression) of claudin-1
1) Confidence 0.09 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.32 Pain Relevance 0.05

General Comments

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