INT303591

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.34
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Crhr1) plasma membrane (Crhr1) response to stress (Crhr1)
signal transducer activity (Crhr1)
Crhr1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 8 100.00 Very High Very High Very High
Dopamine 9 88.88 High High
Neuropeptide 1 77.88 Quite High
Opioid 7 62.40 Quite High
cocaine 19 55.84 Quite High
Pain 1 29.68 Quite Low
Morphine 18 5.00 Very Low Very Low Very Low
addiction 14 5.00 Very Low Very Low Very Low
monoamine 13 5.00 Very Low Very Low Very Low
Nicotine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 3 82.64 Quite High
Body Weight 7 72.40 Quite High
Stress 103 67.48 Quite High
Stupor 2 46.80 Quite Low
Hemorrhage 1 42.64 Quite Low
Pain 1 29.68 Quite Low
Lymphopenia 7 5.00 Very Low Very Low Very Low
Drug Dependence 3 5.00 Very Low Very Low Very Low
Aids-related Complex 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Microarray results indicated the inhibitory effects of corticotropin-releasing factor (CRF) receptor 1 (CRFR1) and GR antagonists (antalarmin and RU486, respectively, blocked 65% of ethanol activation, P < 0.05) on gene expression activation of the B3 subcluster (Figure 4f, g).
Positive_regulation (activation) of Gene_expression (effects) of CRFR1 associated with antagonist
1) Confidence 0.42 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.17
to adult rats increases CRF and the CRF1 receptor mRNA expression in the PVN with a delay of one week after treatment which potentiates the secretion of ACTH and causes a long-term HPA sensitization [51].
Positive_regulation (increases) of Gene_expression (expression) of CRF1 receptor mRNA
2) Confidence 0.03 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2845127 Disease Relevance 0.34 Pain Relevance 0.08

General Comments

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