INT303653

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (DRD2) extracellular space (SST) extracellular region (SST)
plasma membrane (DRD2) cell-cell signaling (SST) signal transducer activity (DRD2)
Anatomy Link Frequency
Calu-6 1
DRD2 (Homo sapiens)
SST (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 106 100.00 Very High Very High Very High
Dopamine 5 100.00 Very High Very High Very High
Potency 3 91.84 High High
antagonist 1 83.64 Quite High
dopamine receptor 1 75.44 Quite High
imagery 6 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 1 94.92 High High
Cancer 87 94.24 High High
Increased Venous Pressure Under Development 4 62.76 Quite High
Diarrhoea 10 62.24 Quite High
Carcinoid 22 60.84 Quite High
Neuroendocrine Cancer 11 50.00 Quite Low
Metastasis 14 28.88 Quite Low
Disease 22 19.04 Low Low
Syndrome 15 5.00 Very Low Very Low Very Low
Insulinoma 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chimeric somatostatin-dopamine compounds (dopastatins) with high affinity for SSTRs 2 and D2 receptor (D2R) (BIM-23A387) or to SSTRs 2, 5 and D2R (BIM-23A760) have been showed to inhibit cell proliferation of the non-small-cell lung cancer cell line Calu-6, which expresses SSTRs 2, 5 and D2R with higher potency and efficacy than SSTR 2 and D2R analogues [99].
D2 receptor Binding (affinity) of somatostatin in Calu-6 associated with dopamine, lung cancer, somatostatin and potency
1) Confidence 0.18 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.45 Pain Relevance 0.54

General Comments

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