INT303657

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.94
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (SSTR2, SST) extracellular space (SST) extracellular region (SST)
plasma membrane (SSTR2) cytoplasm (SSTR2) signal transducer activity (SSTR2)
SSTR2 (Homo sapiens)
SST (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 106 100.00 Very High Very High Very High
imagery 6 42.60 Quite Low
Dopamine 5 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
dopamine receptor 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 3 99.06 Very High Very High Very High
Cancer 87 95.04 Very High Very High Very High
Pancreatic Cancer 4 79.44 Quite High
Neuroendocrine Cancer 11 73.12 Quite High
Malignant Neoplastic Disease 5 65.52 Quite High
Gastrinoma 4 65.20 Quite High
Disease 22 46.44 Quite Low
Apoptosis 9 33.76 Quite Low
Carcinoid 22 5.00 Very Low Very Low Very Low
Syndrome 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several study conducted on pancreatic adenocarcinoma animal models demonstrated that intratumoural SSTR 2 gene transfer (using polyethylenimine synthetic vector) inhibited intratumoural production of somatostatin that was critical for the SSTR 2 antitumoral effect.
Gene_expression (transfer) of SSTR 2 Negative_regulation (inhibited) of Gene_expression (production) of somatostatin associated with adenocarcinoma and somatostatin
1) Confidence 0.30 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.94 Pain Relevance 0.16

General Comments

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