INT303691

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.98
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (AHR) cell morphogenesis (AHR) DNA binding (AHR)
response to stress (AHR) cytoplasm (AHR) signal transducer activity (AHR)
KNG1 (Homo sapiens)
AHR (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 82 100.00 Very High Very High Very High
Nicotine 192 99.86 Very High Very High Very High
Inflammation 46 96.00 Very High Very High Very High
agonist 22 50.00 Quite Low
B1 receptor 14 39.56 Quite Low
b2 receptor 58 37.08 Quite Low
antagonist 14 30.64 Quite Low
cytokine 6 21.84 Low Low
dexamethasone 22 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 46 96.00 Very High Very High Very High
Pulmonary Disease 8 89.08 High High
Asthma 30 88.72 High High
Dislocations 2 76.48 Quite High
Cough 2 48.32 Quite Low
Pressure And Volume Under Development 4 47.92 Quite Low
Injury 2 41.04 Quite Low
Nicotine Addiction 24 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the present study was designed to investigate if long-term exposure to nicotine could induce AHR to bradykinin and des-Arg9-bradykinin through the selective up-regulation of kinin receptors and to explore the underlying intracellular inflammatory signal transduction mechanisms involved, with focus on both MAPK and PDE4.


bradykinin Positive_regulation (induce) of AHR associated with inflammation, nicotine and bradykinin
1) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.49 Pain Relevance 0.35
Thus, the present study was designed to investigate if long-term exposure to nicotine could induce AHR to bradykinin and des-Arg9-bradykinin through the selective up-regulation of kinin receptors and to explore the underlying intracellular inflammatory signal transduction mechanisms involved, with focus on both MAPK and PDE4.


bradykinin Positive_regulation (induce) of AHR associated with inflammation, nicotine and bradykinin
2) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.49 Pain Relevance 0.35

General Comments

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