INT303703

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.91
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bdkrb1) plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
cortex 2
Bdkrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
B1 receptor 143 100.00 Very High Very High Very High
Nicotine 96 99.98 Very High Very High Very High
Hippocampus 44 99.84 Very High Very High Very High
b2 receptor 41 97.12 Very High Very High Very High
depression 181 96.84 Very High Very High Very High
antagonist 107 91.76 High High
Inflammation 75 85.44 High High
antidepressant 48 83.96 Quite High
cytokine 131 74.48 Quite High
dexamethasone 11 72.28 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 28 99.78 Very High Very High Very High
Sprains And Strains 8 98.52 Very High Very High Very High
Depression 217 96.84 Very High Very High Very High
INFLAMMATION 83 85.44 High High
Adhesions 1 78.32 Quite High
Infection 20 73.68 Quite High
Hypothermia 12 30.72 Quite Low
Asthma 15 23.00 Low Low
Disease 14 5.00 Very Low Very Low Very Low
Nicotine Addiction 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of note, the increase of B1 receptor mRNA expression in mice submitted to forced swimming plus LPS treatment was completely absent in TNF?
Positive_regulation (increase) of Transcription (expression) of B1 receptor associated with b1 receptor
1) Confidence 0.21 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.73 Pain Relevance 0.39
Our in vivo data were reinforced by real-time PCR experiments, which demonstrated a marked increase in B1 receptor mRNA expression in hippocampus, and notably, in the cortex of mice submitted to forced swimming plus LPS administration.
Positive_regulation (increase) of Transcription (expression) of B1 receptor in cortex associated with b1 receptor and hippocampus
2) Confidence 0.21 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.58 Pain Relevance 0.77
p55 receptor-knockout mice, and increased B1 receptor mRNA expression was completely absent in this mouse strain.
Positive_regulation (increased) of Neg (absent) Transcription (expression) of B1 receptor associated with targeted disruption, b1 receptor and sprains and strains
3) Confidence 0.21 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC3022820 Disease Relevance 0.63 Pain Relevance 0.39
The increased immobility time following LPS treatment was preceded by an enhancement of hippocampal and cortical B1 receptor mRNA expression (which were maximal at 1 h), and a marked production of TNF?
Positive_regulation (enhancement) of Transcription (expression) of B1 receptor associated with b1 receptor
4) Confidence 0.21 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC3022820 Disease Relevance 0.66 Pain Relevance 0.44
Moreover, YM976 also suppresses nicotine-enhanced kinin receptor mRNA expression.
Positive_regulation (enhanced) of Transcription (expression) of kinin associated with nicotine
5) Confidence 0.17 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.31 Pain Relevance 0.42

General Comments

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