INT303710

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.84
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN)
aging (JUN) nucleus (JUN) DNA binding (JUN)
JUN (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 192 96.80 Very High Very High Very High
bradykinin 82 92.40 High High
Inflammation 46 78.96 Quite High
cytokine 6 68.40 Quite High
depression 2 64.16 Quite High
antagonist 14 50.96 Quite High
agonist 22 50.00 Quite Low
chemokine 2 48.08 Quite Low
B1 receptor 14 47.84 Quite Low
b2 receptor 58 42.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 2 97.32 Very High Very High Very High
Necrosis 2 96.00 Very High Very High Very High
Cancer 2 95.64 Very High Very High Very High
INFLAMMATION 46 78.96 Quite High
Pulmonary Disease 8 78.60 Quite High
Asthma 30 78.24 Quite High
Depression 2 64.16 Quite High
Nicotine Addiction 24 56.80 Quite High
Hypersensitivity 4 38.44 Quite Low
Adhesions 2 34.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of ERK5 and the subsequent transcription of c-JUN, but not ERK1/2, can be blocked by cAMP through PKA [17].
Negative_regulation (blocked) of Transcription (transcription) of c-JUN
1) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.12 Pain Relevance 0.43
Activation of ERK5 and the subsequent transcription of c-JUN, but not ERK1/2, can be blocked by cAMP through cAMP-dependent protein kinase (PKA) [17].
Negative_regulation (blocked) of Transcription (transcription) of c-JUN
2) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.72 Pain Relevance 0.22

General Comments

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