INT303715

Context Info Confidence 0.52 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 7 Disease Relevance 5.52 Pain Relevance 0.62

cell differentiation (MAPK7) cytosol (MAPK7) nucleoplasm (MAPK7) signal transduction (MAPK7) nucleus (MAPK7) cell cycle (MAPK7)

MAPK7 (Homo sapiens)

Pain Link Frequency Relevance Heat Nicotine 192 90.88 bradykinin 82 86.48 Inflammation 61 73.04 depression 2 65.68 cytokine 11 62.48 agonist 22 50.00 chemokine 2 49.60 antagonist 19 45.04 B1 receptor 14 41.92 b2 receptor 58 36.08

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 95 99.74 Apoptosis 27 98.84 Stress 5 97.80 Necrosis 2 97.52 Cancer 12 97.16 Coronary Artery Disease 330 96.80 Pulmonary Disease 8 80.12 Asthma 30 79.76 INFLAMMATION 61 73.04 Neurodegenerative Disease 20 70.48

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RA is known to activate ERK5 (MAPK7), suggesting that the increased expression of ERK5 (MAPK7) in CD34+ cells from CAD patients may be related to an increased sensitivity to RA [26].

Positive_regulation (activate) of MAPK7 associated with coronary artery disease and rheumatoid arthritis

1) Confidence 0.52 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 1.05 Pain Relevance 0

RA is known to activate ERK5 (MAPK7), suggesting that the increased expression of ERK5 (MAPK7) in CD34+ cells from CAD patients may be related to an increased sensitivity to RA [26].

Positive_regulation (activate) of ERK5 associated with coronary artery disease and rheumatoid arthritis

2) Confidence 0.52 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 1.05 Pain Relevance 0

RA is known to activate ERK5 (MAPK7), suggesting that the increased expression of ERK5 (MAPK7) in CD34+ cells from CAD patients may be related to an increased sensitivity to RA [26].

Positive_regulation (activate) of MAPK7 associated with coronary artery disease and rheumatoid arthritis

3) Confidence 0.38 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 1.05 Pain Relevance 0

A downstream target of all of the upregulated MAP kinases (ERK5 (MAPK7), p38?

Positive_regulation (upregulated) of MAPK7

4) Confidence 0.35 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.76 Pain Relevance 0

A downstream target of all of the upregulated MAP kinases (ERK5 (MAPK7), p38?

Positive_regulation (upregulated) of ERK5

5) Confidence 0.35 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.76 Pain Relevance 0

Activation of ERK5 and the subsequent transcription of c-JUN, but not ERK1/2, can be blocked by cAMP through PKA [17].

Positive_regulation (Activation) of ERK5

6) Confidence 0.16 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.12 Pain Relevance 0.42

Activation of ERK5 and the subsequent transcription of c-JUN, but not ERK1/2, can be blocked by cAMP through cAMP-dependent protein kinase (PKA) [17].

Positive_regulation (Activation) of ERK5

7) Confidence 0.12 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.72 Pain Relevance 0.19

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