INT303715

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Context Info
Confidence 0.52
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 5.52
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MAPK7) cytosol (MAPK7) nucleoplasm (MAPK7)
signal transduction (MAPK7) nucleus (MAPK7) cell cycle (MAPK7)
MAPK7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 192 90.88 High High
bradykinin 82 86.48 High High
Inflammation 61 73.04 Quite High
depression 2 65.68 Quite High
cytokine 11 62.48 Quite High
agonist 22 50.00 Quite Low
chemokine 2 49.60 Quite Low
antagonist 19 45.04 Quite Low
B1 receptor 14 41.92 Quite Low
b2 receptor 58 36.08 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 95 99.74 Very High Very High Very High
Apoptosis 27 98.84 Very High Very High Very High
Stress 5 97.80 Very High Very High Very High
Necrosis 2 97.52 Very High Very High Very High
Cancer 12 97.16 Very High Very High Very High
Coronary Artery Disease 330 96.80 Very High Very High Very High
Pulmonary Disease 8 80.12 Quite High
Asthma 30 79.76 Quite High
INFLAMMATION 61 73.04 Quite High
Neurodegenerative Disease 20 70.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RA is known to activate ERK5 (MAPK7), suggesting that the increased expression of ERK5 (MAPK7) in CD34+ cells from CAD patients may be related to an increased sensitivity to RA [26].
Positive_regulation (activate) of MAPK7 associated with coronary artery disease and rheumatoid arthritis
1) Confidence 0.52 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 1.05 Pain Relevance 0
RA is known to activate ERK5 (MAPK7), suggesting that the increased expression of ERK5 (MAPK7) in CD34+ cells from CAD patients may be related to an increased sensitivity to RA [26].
Positive_regulation (activate) of ERK5 associated with coronary artery disease and rheumatoid arthritis
2) Confidence 0.52 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 1.05 Pain Relevance 0
RA is known to activate ERK5 (MAPK7), suggesting that the increased expression of ERK5 (MAPK7) in CD34+ cells from CAD patients may be related to an increased sensitivity to RA [26].
Positive_regulation (activate) of MAPK7 associated with coronary artery disease and rheumatoid arthritis
3) Confidence 0.38 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 1.05 Pain Relevance 0
A downstream target of all of the upregulated MAP kinases (ERK5 (MAPK7), p38?
Positive_regulation (upregulated) of MAPK7
4) Confidence 0.35 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.76 Pain Relevance 0
A downstream target of all of the upregulated MAP kinases (ERK5 (MAPK7), p38?
Positive_regulation (upregulated) of ERK5
5) Confidence 0.35 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.76 Pain Relevance 0
Activation of ERK5 and the subsequent transcription of c-JUN, but not ERK1/2, can be blocked by cAMP through PKA [17].
Positive_regulation (Activation) of ERK5
6) Confidence 0.16 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.12 Pain Relevance 0.42
Activation of ERK5 and the subsequent transcription of c-JUN, but not ERK1/2, can be blocked by cAMP through cAMP-dependent protein kinase (PKA) [17].
Positive_regulation (Activation) of ERK5
7) Confidence 0.12 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.72 Pain Relevance 0.19

General Comments

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