INT30372

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Context Info
Confidence 0.60
First Reported 1985
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 0.57
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ADRB3) aging (ADRB3) plasma membrane (ADRB3)
nucleus (ADRB3) carbohydrate metabolic process (ADRB3) signal transducer activity (ADRB3)
Anatomy Link Frequency
spinal 2
blood 1
lymphocytes 1
proximal 1
PBMC 1
ADRB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 101 99.96 Very High Very High Very High
Regional anesthesia 8 99.82 Very High Very High Very High
antagonist 33 97.64 Very High Very High Very High
Calcium channel 8 97.16 Very High Very High Very High
anesthesia 4 95.36 Very High Very High Very High
Morphine 1 92.00 High High
Paracetamol 1 91.20 High High
cINOD 1 84.80 Quite High
adenocard 8 83.00 Quite High
Bioavailability 1 72.88 Quite High
Disease Link Frequency Relevance Heat
Stress 8 98.96 Very High Very High Very High
Premature Birth 20 98.20 Very High Very High Very High
Functional Bowel Disorder 1 71.84 Quite High
Pre-term Labor 8 71.76 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

3 69.76 Quite High
Asthma 2 36.60 Quite Low
Obesity 8 5.00 Very Low Very Low Very Low
Dysmenorrhea 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of cesarean delivery on perioperative regulation of the beta-adrenergic receptor system of human lymphocytes.
Regulation (regulation) of beta-adrenergic receptor in lymphocytes
1) Confidence 0.60 Published 1996 Journal Anesth. Analg. Section Title Doc Link 8610861 Disease Relevance 0.06 Pain Relevance 0.24
We studied the perioperative regulation of the beta-adrenergic receptor (beta AR) system in lymphocytes obtained before and after surgery from 12 patients undergoing cesarean delivery with spinal anesthesia.
Regulation (regulation) of beta-adrenergic receptor in spinal associated with anesthesia
2) Confidence 0.60 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8610861 Disease Relevance 0 Pain Relevance 0.13
We studied the perioperative regulation of the beta-adrenergic receptor (beta AR) system in lymphocytes obtained before and after surgery from 12 patients undergoing cesarean delivery with spinal anesthesia.
Regulation (regulation) of beta AR in spinal associated with anesthesia
3) Confidence 0.60 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8610861 Disease Relevance 0 Pain Relevance 0.13
Indeed clinical trials, that were designed to assess the effect of ADRB3 agonists on human metabolism, did not reveal any significant change in heart rate, blood pressure, plasma glucose, insulin or potassium levels [37].
Regulation (effect) of ADRB3 in blood associated with agonist
4) Confidence 0.45 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0.07 Pain Relevance 0.46
Sulphate conjugation is particularly important for steriod hormones such as ethinyloestradiol, and for the beta-adrenoceptor stimulants isoprenaline and isoetharine.
Regulation (important) of beta-adrenoceptor
5) Confidence 0.40 Published 1987 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 2979678 Disease Relevance 0 Pain Relevance 0.22
Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?


Regulation (target) of beta3-adrenoceptor
6) Confidence 0.27 Published 2007 Journal BMC Pregnancy Childbirth Section Title Doc Link PMC1892055 Disease Relevance 0.10 Pain Relevance 0.07
RT-PCR experiments and PDE4 activity measurement were performed in order to assess some of the mechanisms that could be involved in desensitization process and we found that neither ADRB2 and ADRB3 mRNA expression levels nor PDE4 activity were affected by salbutamol or SR 59119A treatments.


Neg (neither) Regulation (affected) of ADRB3
7) Confidence 0.27 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.07
Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?


Regulation (target) of ADRB3
8) Confidence 0.27 Published 2007 Journal BMC Pregnancy Childbirth Section Title Doc Link PMC1892055 Disease Relevance 0.10 Pain Relevance 0.07
It is possible that this difference in response is due to amelioration of the stress response to surgery by regional anesthesia, and/or alterations in beta AR status by pregnancy.
Regulation (alterations) of beta AR associated with stress and regional anesthesia
9) Confidence 0.26 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8610861 Disease Relevance 0.10 Pain Relevance 0.30
The present study was initiated to investigate whether there is a physiological, beta adrenergic influence on human GI motility and to describe the effects of selective beta adrenoceptor stimulation on motility in the proximal and distal parts of the GI tract.
Regulation (effects) of beta adrenoceptor in proximal
10) Confidence 0.21 Published 1985 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 2864739 Disease Relevance 0.07 Pain Relevance 0.26
Together, the present data provide clear evidence for concentration-dependent effects of beta-adrenoceptor agonists on the IL-4 and IFN-gamma production by human PBMC.
Regulation (effects) of beta-adrenoceptor in PBMC associated with agonist
11) Confidence 0.19 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0 Pain Relevance 0.29

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