INT303745

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.04
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) plasma membrane (Chrm3)
carbohydrate metabolic process (Ins1) cytoplasm (Ins1) signal transducer activity (Chrm3)
Anatomy Link Frequency
cerebellum 2
Chrm3 (Rattus norvegicus)
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuronal excitability 2 86.72 High High
Neurotransmitter 5 79.60 Quite High
Central nervous system 10 75.40 Quite High
depression 2 67.60 Quite High
Eae 1 12.24 Low Low
Glutamate 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoglycemia 39 99.64 Very High Very High Very High
Diabetes Mellitus 74 98.80 Very High Very High Very High
Cognitive Disorder 15 85.36 High High
Brain Injury 3 81.96 Quite High
Neurodegenerative Disease 1 78.12 Quite High
Cv Unclassified Under Development 1 77.24 Quite High
Disease 3 74.20 Quite High
Apoptosis 1 69.60 Quite High
Depression 2 67.60 Quite High
Death 2 32.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, enhanced muscarinic M1 and M3 receptor binding in the cerebellum of insulin induced hypoglycemia in both diabetic and nondiabetic rats along with increased AchE activity and decreased ChAT expression shows altered acetylcholine metabolism in the cerebellum.
Positive_regulation (enhanced) of M3 receptor Binding (binding) of insulin in cerebellum associated with hypoglycemia and diabetes mellitus
1) Confidence 0.05 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2845573 Disease Relevance 1.04 Pain Relevance 0.15

General Comments

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