INT3038

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Context Info
Confidence 0.78
First Reported 1975
Last Reported 2011
Negated 19
Speculated 8
Reported most in Body
Documents 1583
Total Number 1591
Disease Relevance 1174.16
Pain Relevance 107.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
plasma 94
blood 79
body 28
pancreas 26
fat 25
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 7305 100.00 Very High Very High Very High
Inflammatory response 544 100.00 Very High Very High Very High
Somatostatin 262 100.00 Very High Very High Very High
Dopamine 84 100.00 Very High Very High Very High
dexamethasone 72 100.00 Very High Very High Very High
Clonidine 63 100.00 Very High Very High Very High
Analgesic 16 100.00 Very High Very High Very High
Nerve growth factor 8 100.00 Very High Very High Very High
Arthritis 434 99.96 Very High Very High Very High
Catecholamine 250 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 70019 100.00 Very High Very High Very High
Obesity 17720 100.00 Very High Very High Very High
Insulin Resistance 16049 100.00 Very High Very High Very High
Hypoglycemia 14624 100.00 Very High Very High Very High
INFLAMMATION 8612 100.00 Very High Very High Very High
Metabolic Syndrome 7260 100.00 Very High Very High Very High
Impaired Glucose Tolerance 3669 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 3532 100.00 Very High Very High Very High
Hyperinsulinism 2789 100.00 Very High Very High Very High
Aging 2332 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Even though the ultimate goal would be to eliminate the need to deliver insulin exogenously and regaining the ability of patients to produce and use own insulin, new concepts are currently explored to deliver insulin using oral, pulmonary, nasal, ocular and rectal routes.
Gene_expression (produce) of insulin in nasal
1) Confidence 0.78 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792528 Disease Relevance 0.47 Pain Relevance 0.17
Nowadays, the major advances achieved in this area include the human insulin analogue synthesis from the recombinant DNA techniques23.
Gene_expression (synthesis) of insulin
2) Confidence 0.78 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792528 Disease Relevance 0.26 Pain Relevance 0
Compared with metformin plus a sulfonylurea, inhaled insulin in combination with a sulfonylurea produced a significantly greater reduction in HbA1c in patients with a baseline HbA1c value >9.5%.
Gene_expression (produced) of insulin
3) Confidence 0.78 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994047 Disease Relevance 0.37 Pain Relevance 0
Valentine and colleagues (2006) in the US applied economic data to a single RCT in which insulin detemir was found to produce significantly less hypoglycemia than insulin glargine.
Gene_expression (produce) of insulin associated with hypoglycemia
4) Confidence 0.78 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.46 Pain Relevance 0
The results from six of these large controlled trials (level 2 evidence) comparing subcutaneous insulin glargine with subcutaneous NPH insulin show that over a period of up to 1 year, both insulin glargine and NPH insulin produced clinically significant improvements in glycemic control with some trials reporting high response rates.
Gene_expression (produced) of NPH insulin
5) Confidence 0.78 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.08 Pain Relevance 0
permanent lack of insulin production from the pancreas due to the destruction
Gene_expression (production) of insulin in pancreas
6) Confidence 0.77 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 1.30 Pain Relevance 0
less internal insulin production [17].
Gene_expression (production) of insulin in internal
7) Confidence 0.77 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 1.42 Pain Relevance 0
of the insulin production by the pancreas immediately causes metabolic
Gene_expression (production) of insulin in pancreas
8) Confidence 0.77 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 1.15 Pain Relevance 0
This study seems to indicate that hyperproduction of endogenous opioid peptides in obesity increases insulin secretion stimulated by food intake, whereas it does not appreciably affect insulin production stimulated by circulating glucose or aminoacids.
Gene_expression (production) of insulin associated with obesity and endogenous opioid
9) Confidence 0.77 Published 1989 Journal Int J Obes Section Abstract Doc Link 2529225 Disease Relevance 0.48 Pain Relevance 0.44
This study examined in vivo the interstitial appearance of insulin in hindlimb using the fatty acid acylated insulin analog Lys(B29)-tetradecanoyl des-(B30) human insulin, or NN304, as a marker for insulin transport.
Gene_expression (appearance) of insulin in B29
10) Confidence 0.77 Published 2002 Journal Diabetes Section Abstract Doc Link 11872653 Disease Relevance 0.27 Pain Relevance 0
The central element in the development and progression of diabetes is the progressive loss of insulin production and/or insulin sensitivity, leading to dysregulation of systemic glucose utilization and increased BG concentrations.
Gene_expression (production) of insulin associated with diabetes mellitus
11) Confidence 0.77 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350138 Disease Relevance 1.40 Pain Relevance 0.06
Basal NPH insulin produces a maximal insulin concentration 4–6 hours after injection, which can cause hypoglycemia and often necessitates twice-daily injections (Zinman et al 1999).
Gene_expression (produces) of insulin associated with hypoglycemia
12) Confidence 0.77 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993975 Disease Relevance 0.57 Pain Relevance 0
The mitogenic activity of insulin glargine was not increased compared with regular human insulin in in vitro tests using cell lines that mainly express insulin receptors (Berti et al 1998).
Gene_expression (express) of insulin
13) Confidence 0.77 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993975 Disease Relevance 0.44 Pain Relevance 0.03
Basal NPH insulin produces a maximal insulin concentration 4–6 hours after injection, which can cause hypoglycemia and often necessitates twice-daily injections (Zinman et al 1999).
Gene_expression (produces) of NPH insulin associated with hypoglycemia
14) Confidence 0.77 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993975 Disease Relevance 0.57 Pain Relevance 0
It is an analogue of human insulin that is produced in a non-pathogenic strain of Escherichia coli.
Gene_expression (produced) of insulin associated with sprains and strains
15) Confidence 0.77 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993975 Disease Relevance 0.18 Pain Relevance 0
In fact, as of October 18, 2007, Pfizer Inc. halted production of its inhaled insulin powder due to lack of uptake of the product; however, there are other devices in development.
Gene_expression (production) of insulin
16) Confidence 0.77 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 0.29 Pain Relevance 0
Recombinant DNA technology has produced insulin analogs – insulin glargine and insulin detemir – with structural modifications that improve their time-action profiles such that they more closely resemble physiologic insulin patterns [33].
Gene_expression (produced) of insulin
17) Confidence 0.77 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 0.14 Pain Relevance 0
With the implantable insulin delivery pump, insulin is introduced into the peritoneum, which is closer to physiologic delivery and absorption.
Gene_expression (introduced) of insulin in peritoneum
18) Confidence 0.77 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC2877202 Disease Relevance 0 Pain Relevance 0
With the implantable insulin delivery pump, insulin is introduced into the peritoneum, which is closer to physiologic delivery and absorption.
Gene_expression (introduced) of insulin in peritoneum
19) Confidence 0.77 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC2877202 Disease Relevance 0 Pain Relevance 0
The similarities between islet cells and neurons are further underscored by the demonstration of insulin gene transcription in the vertebrate brain [5], although it remains unclear whether these vertebrate neurons produce or secrete insulin protein [6].
Gene_expression (produce) of insulin in brain
20) Confidence 0.76 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.07 Pain Relevance 0

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