INT30381

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Context Info
Confidence 0.54
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.19
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CLPP) mitochondrion (CLPP)
Anatomy Link Frequency
cerebrospinal fluid 1
CLPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 6 98.32 Very High Very High Very High
Opioid 1 75.00 Quite High
Dynorphin 1 59.28 Quite High
Disease Link Frequency Relevance Heat
Rickets 1 97.12 Very High Very High Very High
Osteoporosis 1 91.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An endopeptidase releasing the common N-terminal hexapeptide, (Leu)-enkephalin-Arg6, from dynorphins A and B, and alpha-neoendorphin was purified from human cerebrospinal fluid.
Localization (releasing) of endopeptidase in cerebrospinal fluid associated with enkephalin
1) Confidence 0.54 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2864927 Disease Relevance 0 Pain Relevance 0.20
For instance, while there is hallmark evidence for the importance of the endopeptidase Phex, whose inactivation in Hyp mice or human patients causes X-linked hypophosphatemic rickets, it is still largely unknown how Phex controls bone mineralization since a physiological substrate for its endopeptidase activity has not been identified yet.
Localization (importance) of endopeptidase associated with rickets
2) Confidence 0.06 Published 2010 Journal Calcif. Tissue Int. Section Abstract Doc Link 20204609 Disease Relevance 0.19 Pain Relevance 0.12

General Comments

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