INT303837

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 15
Disease Relevance 11.08
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pon1) extracellular region (Pon1) lipid metabolic process (Pon1)
Anatomy Link Frequency
liver 6
heart 1
Pon1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 181 97.88 Very High Very High Very High
anesthesia 30 58.88 Quite High
ischemia 24 50.00 Quite Low
chemokine 12 46.40 Quite Low
alcohol 12 33.60 Quite Low
Inflammatory response 12 32.24 Quite Low
cytokine 12 25.16 Quite Low
imagery 12 5.04 Very Low Very Low Very Low
fibrosis 24 5.00 Very Low Very Low Very Low
ketamine 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 14 99.78 Very High Very High Very High
Stress 141 99.62 Very High Very High Very High
Liver Disease 169 99.56 Very High Very High Very High
Disorder Of Lipid Metabolism 889 99.30 Very High Very High Very High
Injury 22 98.84 Very High Very High Very High
Congenital Anomalies 24 98.32 Very High Very High Very High
INFLAMMATION 193 97.88 Very High Very High Very High
Cirrhosis 204 97.28 Very High Very High Very High
Fibrosis 36 94.32 High High
Death 6 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They also showed a profound decrease in serum PON1 activity and an increase in PON1 concentration, together with an increase in total peroxides, MCP-1, and P-III-P concentrations (Table 1).
Negative_regulation (decrease) of PON1
1) Confidence 0.57 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.21 Pain Relevance 0
PON1 activity was significantly decreased, and PON1 concentration was significantly increased in the patient group relative to controls.
Negative_regulation (decreased) of PON1
2) Confidence 0.57 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.39 Pain Relevance 0
In previous studies, we reported that serum PON1 activity is decreased in patients with chronic liver impairment, while serum PON1 concentration and hepatic PON1 protein expression are increased [21-23].
Negative_regulation (decreased) of PON1 in liver
3) Confidence 0.57 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.18 Pain Relevance 0.13
In addition, results from the present study suggest that these small particles do not carry PON1 and, as such, would contribute to the decrease in serum PON1 activity observed.
Negative_regulation (decrease) of PON1
4) Confidence 0.57 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.94 Pain Relevance 0.05
A possible answer to the question of why serum PON1 activity is decreased is that PON1 is inactivated by oxidized lipids, as was shown by Aviram et al. [39] who demonstrated that the incubation of PON1 in vitro with oxidized palmitoyl arachidonoyl phosphatidylcholine, lysophosphatidylcholine, oxidized cholesteryl arachidonate and oxidized LDL resulted in inactivation of PON1 arylesterase activity.
Negative_regulation (inactivation) of PON1
5) Confidence 0.42 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.76 Pain Relevance 0.07
Chronic liver diseases are characterized by decreased serum PON1 activity.
Negative_regulation (decreased) of PON1 in liver associated with liver disease
6) Confidence 0.42 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2877049 Disease Relevance 0.52 Pain Relevance 0.05
As stated before, case-control studies showing a decreased serum PON1 activity and increased PON1 concentration have already been published [21-23], and the aim of the present investigation was to add a further insight into the hypothesis that these changes may be related to other HDL compositional alterations.
Negative_regulation (decreased) of PON1 associated with disorder of lipid metabolism
7) Confidence 0.42 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.83 Pain Relevance 0.07
We conclude that abnormalities in the composition of lipids and proteins of HDL particles are associated with the decrease in serum PON1 activity in patients with liver disease.
Negative_regulation (decrease) of PON1 in liver associated with liver disease, congenital anomalies and disorder of lipid metabolism
8) Confidence 0.42 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.17 Pain Relevance 0.04
All these changes were observed to be strongly associated with a decrease in serum PON1 activity.
Negative_regulation (decrease) of PON1
9) Confidence 0.42 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.09 Pain Relevance 0.09
Indeed, in a previous study, we observed that alcoholic patients with a normal, or with minimally-affected liver function, already had a decreased serum PON1 activity that was associated with an increase in the circulating concentration of malondialdehyde [23].
Negative_regulation (decreased) of PON1 in liver
10) Confidence 0.42 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.73 Pain Relevance 0.06
Abnormalities in the composition of lipids and proteins of HDL particles, including PON1 glycosylation, are associated with the decrease in serum PON1 activity in patients with liver disease.
Negative_regulation (decrease) of PON1 in liver associated with liver disease, congenital anomalies and disorder of lipid metabolism
11) Confidence 0.42 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2877049 Disease Relevance 0.85 Pain Relevance 0.05
Decreased paraoxonase-1 activity is associated with alterations of high-density lipoprotein particles in chronic liver impairment

Background

Negative_regulation (Decreased) of paraoxonase-1 in liver
12) Confidence 0.37 Published 2010 Journal Lipids Health Dis Section Title Doc Link PMC2877049 Disease Relevance 0.58 Pain Relevance 0.04
Recently, roles for PON1 in a number of processes have been studied, including lipid and lipoprotein metabolism, as well as for their antiatherogenic and antioxidant properties.16–20 Oxidative stress, which is the result of an increased number of lipid and protein oxidation products and decreased number of antioxidant enzymes and vitamins, has been reported to affect the expression and activities of PON1.16, 20 Furthermore, oxidative stress has been shown to decrease PON1 activity and down-regulate the serum expression of PON1.16, 21–24
Negative_regulation (decrease) of PON1 associated with stress
13) Confidence 0.35 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845769 Disease Relevance 0.74 Pain Relevance 0.06
Propofol improved myocardial contractility, reduced myocardial infarct size, and decreased serum cTn-I levels after a regional I/R injury in an in vivo rat heart model after 48 h of reperfusion.
Negative_regulation (decreased) of serum cTn-I in heart associated with injury and myocardial infarction
14) Confidence 0.10 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2876860 Disease Relevance 0.58 Pain Relevance 0
The I/R-induced serum cTn-I level was reduced by propofol infusion during the peri-ischemic period.


Negative_regulation (reduced) of serum cTn-I
15) Confidence 0.08 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2876860 Disease Relevance 0.51 Pain Relevance 0

General Comments

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