INT30386

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Context Info
Confidence 0.52
First Reported 1983
Last Reported 2008
Negated 2
Speculated 4
Reported most in Abstract
Documents 33
Total Number 37
Disease Relevance 4.34
Pain Relevance 23.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRD1) cytoplasm (OPRD1) signal transducer activity (OPRD1)
Anatomy Link Frequency
NG108-15 2
PGE1 1
immune system 1
embryonic kidney 1
ovary 1
OPRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 150 100.00 Very High Very High Very High
Delta opioid receptors 32 100.00 Very High Very High Very High
Opioid 27 100.00 Very High Very High Very High
antagonist 17 100.00 Very High Very High Very High
Immobilon 17 100.00 Very High Very High Very High
agonist 90 99.92 Very High Very High Very High
Cannabinoid receptor 1 99.92 Very High Very High Very High
Enkephalin 56 99.86 Very High Very High Very High
Analgesic 8 99.86 Very High Very High Very High
Morphine 32 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 1 100.00 Very High Very High Very High
Depression 2 99.36 Very High Very High Very High
Neuroblastoma 15 99.20 Very High Very High Very High
Respiratory Tract Infection 1 98.28 Very High Very High Very High
Stress 12 97.88 Very High Very High Very High
Convulsion 9 97.58 Very High Very High Very High
Anxiety Disorder 5 97.28 Very High Very High Very High
Glioma 2 95.52 Very High Very High Very High
Bordatella Infection 5 94.40 High High
Pain 6 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Selective and interactive down-regulation of mu- and delta-opioid receptors in human neuroblastoma SK-N-SH cells.
Negative_regulation (down-regulation) of delta-opioid in SK-N-SH associated with neuroblastoma, analgesic and delta opioid receptors
1) Confidence 0.52 Published 1993 Journal Mol. Pharmacol. Section Title Doc Link 8394999 Disease Relevance 0.20 Pain Relevance 1.08
Agonist-specific down-regulation of the human delta-opioid receptor.
Negative_regulation (down-regulation) of delta-opioid receptor associated with agonist and opioid receptor
2) Confidence 0.51 Published 2003 Journal Eur. J. Pharmacol. Section Title Doc Link 12505529 Disease Relevance 0 Pain Relevance 0.82
In the present study, we examined the down-regulation of the truncated human delta-opioid receptor by structurally distinct delta-opioid receptor agonists.
Spec (examined) Negative_regulation (down-regulation) of delta-opioid receptor associated with agonist and opioid receptor
3) Confidence 0.51 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12505529 Disease Relevance 0 Pain Relevance 0.76
These effects were completely antagonized by a selective delta-opioid-receptor antagonist, naltrindole.
Negative_regulation (antagonist) of delta-opioid-receptor associated with antagonist and opioid
4) Confidence 0.42 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15272214 Disease Relevance 0.59 Pain Relevance 0.66
These results demonstrate that the molecular mechanism of the human delta-opioid receptor down-regulation is agonist-specific.
Negative_regulation (down-regulation) of delta-opioid receptor associated with agonist and opioid receptor
5) Confidence 0.42 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14757159 Disease Relevance 0 Pain Relevance 0.46
The present study investigated the role of Ser(363) in human delta-opioid receptor down-regulation by a delta-selective peptide- and non-peptide agonist.
Spec (investigated) Negative_regulation (down-regulation) of delta-opioid receptor associated with agonist and opioid receptor
6) Confidence 0.42 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14757159 Disease Relevance 0 Pain Relevance 0.48
Differential down-regulation of the human delta-opioid receptor by SNC80 and [D-Pen(2),D-Pen(5)]enkephalin.
Negative_regulation (down-regulation) of delta-opioid receptor associated with enkephalin and opioid receptor
7) Confidence 0.40 Published 2000 Journal Eur. J. Pharmacol. Section Title Doc Link 10650167 Disease Relevance 0 Pain Relevance 0.37
Addition of the hydroxyl group to RTI5989-54 (RTI5989-61) or replacement of the allyl group with the trans-crotyl group on the piperidine nitrogen of RTI-5989-61 (RTI5989-62) increased binding affinity, produced full agonist activity, and decreased intrinsic efficacy at the delta opioid receptor.
Negative_regulation (decreased) of delta opioid receptor associated with respiratory tract infection, agonist and opioid receptor
8) Confidence 0.40 Published 2001 Journal Synapse Section Abstract Doc Link 11309842 Disease Relevance 0.10 Pain Relevance 0.51
Phosphorylation of S363 may contribute to delta-opioid receptor desensitization by morphine.
Negative_regulation (desensitization) of delta-opioid receptor associated with opioid receptor and morphine
9) Confidence 0.38 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16135360 Disease Relevance 0 Pain Relevance 0.54
These findings suggest that SNC80-mediated phosphorylation and down-regulation of the human delta-opioid receptor involves other receptor domains in addition to the carboxy terminus.
Negative_regulation (down-regulation) of delta-opioid receptor associated with opioid receptor
10) Confidence 0.37 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12505529 Disease Relevance 0.09 Pain Relevance 0.75
Down-regulation of the delta-opioid receptor contributes to the development of tolerance to delta-opioid receptor agonists.
Negative_regulation (Down-regulation) of delta-opioid receptor associated with agonist, tolerance and opioid receptor
11) Confidence 0.37 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12505529 Disease Relevance 0 Pain Relevance 0.56
Inhibition of agonist-induced down-regulation of the delta-opioid receptor with a proteasome inhibitor attenuates opioid tolerance in human embryonic kidney 293 cells.
Negative_regulation (regulation) of delta-opioid receptor in embryonic kidney associated with tolerance, agonist, opioid receptor and opioid
12) Confidence 0.37 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 17159161 Disease Relevance 0 Pain Relevance 1.28
Desensitization of the delta-opioid receptor correlates with its phosphorylation in SK-N-BE cells: involvement of a G protein-coupled receptor kinase.
Negative_regulation (Desensitization) of delta-opioid receptor associated with opioid receptor and immobilon
13) Confidence 0.37 Published 1998 Journal J. Neurochem. Section Title Doc Link 9572300 Disease Relevance 0 Pain Relevance 0.47
Both SNC80 and DPDPE mediated down-regulation of an epitope tagged human delta-opioid receptor.
Negative_regulation (down-regulation) of delta-opioid receptor associated with opioid receptor
14) Confidence 0.35 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10650167 Disease Relevance 0 Pain Relevance 0.35
The role of mu-opioid receptors in morphine-induced delta receptor down-regulation was studied by using the irreversible mu antagonist beta-funaltrexamine.
Negative_regulation (down-regulation) of delta receptor associated with antagonist, mu opioid receptor and morphine
15) Confidence 0.33 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8394999 Disease Relevance 0.13 Pain Relevance 1.28
NG108-15 cells did not exhibit delta-opioid receptor down-regulation when exposed to morphine.
Neg (not) Negative_regulation (down-regulation) of delta-opioid receptor in NG108-15 associated with opioid receptor and morphine
16) Confidence 0.33 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8394999 Disease Relevance 0.15 Pain Relevance 1.12
The experimental data indicate that morphine-induced delta-opioid receptor down-regulation is dependent on the presence of functional mu receptors in the same cell.
Negative_regulation (down-regulation) of delta-opioid receptor associated with opioid receptor and morphine
17) Confidence 0.33 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8394999 Disease Relevance 0.07 Pain Relevance 1.13
In the present study, we examined desensitization of the human delta-opioid receptor (hDOR) produced by endogenous opioid peptides Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met), and the contribution of internalization in this process.
Spec (examined) Negative_regulation (desensitization) of delta-opioid receptor associated with endogenous opioid, enkephalin and opioid receptor
18) Confidence 0.27 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15102931 Disease Relevance 0 Pain Relevance 0.76
These studies showed that SNC-80 produced desensitization and down-regulation of human delta-opioid receptors in recombinant Chinese hamster ovary cells after chronic treatment and that this effect was associated with an increase in adenylyl cyclase activity.
Negative_regulation (down-regulation) of delta-opioid in ovary associated with delta opioid receptors
19) Confidence 0.25 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8819489 Disease Relevance 0 Pain Relevance 0.39
Furthermore, since only the changes in seizure threshold were antagonized, it may be inferred that opioid-induced behavioral depression and DADLE wet-shakes are not a function of delta-receptor activity.
Negative_regulation (function) of delta-receptor associated with convulsion, depression and opioid
20) Confidence 0.11 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319916 Disease Relevance 0.78 Pain Relevance 0.46

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