INT303866

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (NAA50, CACNA1C) small molecule metabolic process (CACNA1C) plasma membrane (CACNA1C)
transferase activity, transferring acyl groups (NAA50) transmembrane transport (CACNA1C)
Anatomy Link Frequency
myocardium 3
NAA50 (Homo sapiens)
CACNA1C (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 29 78.04 Quite High
fibrosis 2 9.72 Low Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
action potential duration 2 5.00 Very Low Very Low Very Low
Nav1.1 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 6 78.40 Quite High
Obesity 3 50.00 Quite Low
Fibrosis 5 9.72 Low Low
Aging 11 5.00 Very Low Very Low Very Low
Heart Rate Under Development 9 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the guinea pig, we have previously shown an age-dependent increase in SAN tissue lacking expression of Cx43 and Cav1.2 (major L-type Ca2+ channel isoform in working myocardium) [27,28].
Positive_regulation (increase) of SAN in myocardium Negative_regulation (lacking) of Neg (lacking) Gene_expression (expression) of Cav1.2 in myocardium
1) Confidence 0.13 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.08 Pain Relevance 0.16

General Comments

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