INT303879

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.08
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CACNA1C) plasma membrane (CACNA1C) transmembrane transport (CACNA1C)
cytoplasm (CACNA1C)
Anatomy Link Frequency
myocardium 2
neural 2
CACNA1C (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 12 95.88 Very High Very High Very High
Action potential 30 78.04 Quite High
addiction 1 49.76 Quite Low
fibrosis 2 9.72 Low Low
sodium channel 4 5.00 Very Low Very Low Very Low
potassium channel 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Calcium channel 3 5.00 Very Low Very Low Very Low
action potential duration 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 6 78.40 Quite High
Obesity 22 50.00 Quite Low
Fibrosis 5 9.72 Low Low
Aging 11 5.00 Very Low Very Low Very Low
Heart Rate Under Development 9 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the guinea pig, we have previously shown an age-dependent increase in SAN tissue lacking expression of Cx43 and Cav1.2 (major L-type Ca2+ channel isoform in working myocardium) [27,28].
Positive_regulation (increase) of Neg (lacking) Gene_expression (expression) of Cav1.2 in myocardium
1) Confidence 0.49 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.08 Pain Relevance 0.16
Following neural differentiation with bFGF and forskolin, the gene expression levels of MaxiK, Kv4.2, Eag2, SCN5A, CACNA1C, and CACNA1G in NI-hADSCs were significantly higher than in the primary hADSCs (Figure 4d, 4e).
Positive_regulation (higher) of Gene_expression (levels) of CACNA1C in neural
2) Confidence 0.37 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox