INT303880

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.08
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (NAA50) cytoplasm (NAA50)
Anatomy Link Frequency
muscle 4
heart 2
NAA50 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 12 95.88 Very High Very High Very High
Action potential 87 93.56 High High
fibrosis 6 78.08 Quite High
action potential duration 6 5.00 Very Low Very Low Very Low
Nav1.1 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 27 98.68 Very High Very High Very High
Targeted Disruption 3 95.72 Very High Very High Very High
Fibrosis 15 85.28 High High
Necrosis 3 74.28 Quite High
Cancer 3 73.92 Quite High
Hypertrophy 18 69.48 Quite High
Aging 33 58.32 Quite High
Obesity 9 50.00 Quite Low
Disease 3 36.84 Quite Low
Body Weight 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The abundance of MMP2 mRNA was similar in all tissues and there was a significant age-dependent decrease in MMP2 mRNA in the SAN head and atrial muscle at least (Fig. 7A).
Negative_regulation (decrease) of Gene_expression (head) of SAN in muscle
1) Confidence 0.14 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.44 Pain Relevance 0.18
However, the increase in SAN tissue lacking expression of Nav1.5 cannot explain the age-dependent decrease in the intrinsic heart rate, because blockade of Nav1.5 by 2 ?
Negative_regulation (lacking) of Gene_expression (expression) of SAN in heart
2) Confidence 0.12 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.34 Pain Relevance 0.04
The increase in SAN tissue lacking expression of Nav1.5 possibly could help explain the increase in the SAN conduction time observed in the elderly and SAN exit block in sick sinus syndrome [30] if the SAN action potential has to propagate a greater distance from the leading pacemaker site in the SAN through tissue lacking Nav1.5 to reach the surrounding atrial muscle [2].
Negative_regulation (lacking) of Gene_expression (expression) of SAN in muscle associated with action potential and heart rate under development
3) Confidence 0.12 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.30 Pain Relevance 0.05

General Comments

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