INT303881

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.90
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (NAA50) cytoplasm (NAA50)
Anatomy Link Frequency
extracellular matrix 2
NAA50 (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 58 98.88 Very High Very High Very High
metalloproteinase 8 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
action potential duration 4 5.00 Very Low Very Low Very Low
Nav1.1 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 6 99.94 Very High Very High Very High
Hypertrophy 12 96.20 Very High Very High Very High
Aging 22 88.36 High High
Heart Rate Under Development 18 82.44 Quite High
Cardiovascular Disease 2 62.88 Quite High
Fibrosis 10 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, there is electrophysiological evidence of an enlargement of the SAN: Alings and Bouman [3] showed that, in the rabbit and cat, the SAN region with a ‘slow action potential’ increases with age—it has been suggested that this is responsible for the decline in SAN function [4].
Regulation (responsible) of Negative_regulation (decline) of SAN associated with action potential
1) Confidence 0.13 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.54 Pain Relevance 0.18
It is concluded that the age- (and/or obesity-) dependent decline in SAN function is associated with a structural remodelling of the SAN: an enlargement of the SAN, a hypertrophy of the SAN cells, and a remodelling of the extracellular matrix.



Regulation (dependent) of Negative_regulation (decline) of SAN in extracellular matrix associated with hypertrophy and obesity
2) Confidence 0.08 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Abstract Doc Link PMC2845824 Disease Relevance 0.36 Pain Relevance 0.07

General Comments

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