INT303882

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.72
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (NAA50) cytoplasm (NAA50)
Anatomy Link Frequency
myocardium 2
muscle 2
heart 2
NAA50 (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 87 93.56 High High
fibrosis 6 9.72 Low Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
action potential duration 6 5.00 Very Low Very Low Very Low
Nav1.1 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 27 99.16 Very High Very High Very High
Targeted Disruption 3 96.20 Very High Very High Very High
Hypertrophy 18 76.88 Quite High
Aging 33 58.32 Quite High
Obesity 9 50.00 Quite Low
Fibrosis 15 9.72 Low Low
Body Weight 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the increase in SAN tissue lacking expression of Nav1.5 cannot explain the age-dependent decrease in the intrinsic heart rate, because blockade of Nav1.5 by 2 ?
Positive_regulation (increase) of Gene_expression (expression) of SAN in heart
1) Confidence 0.14 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.34 Pain Relevance 0.04
The increase in SAN tissue lacking expression of Nav1.5 possibly could help explain the increase in the SAN conduction time observed in the elderly and SAN exit block in sick sinus syndrome [30] if the SAN action potential has to propagate a greater distance from the leading pacemaker site in the SAN through tissue lacking Nav1.5 to reach the surrounding atrial muscle [2].
Positive_regulation (increase) of Gene_expression (expression) of SAN in muscle associated with action potential and heart rate under development
2) Confidence 0.14 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.30 Pain Relevance 0.05
In the guinea pig, we have previously shown an age-dependent increase in SAN tissue lacking expression of Cx43 and Cav1.2 (major L-type Ca2+ channel isoform in working myocardium) [27,28].
Positive_regulation (increase) of Gene_expression (expression) of SAN in myocardium
3) Confidence 0.14 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.08 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox