INT303885

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.68
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Serpinh1) endoplasmic reticulum (Serpinh1) protein maturation (Serpinh1)
response to stress (Serpinh1) cytoplasm (Serpinh1)
Anatomy Link Frequency
muscle 1
fibroblast 1
lung 1
Serpinh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 63 96.00 Very High Very High Very High
metalloproteinase 21 90.20 High High
chemokine 2 90.20 High High
cytokine 7 89.60 High High
Inflammation 32 89.20 High High
Action potential 116 5.00 Very Low Very Low Very Low
action potential duration 8 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
Nav1.1 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 1 100.00 Very High Very High Very High
Pulmonary Fibrosis 12 96.20 Very High Very High Very High
INFLAMMATION 30 89.20 High High
Disease 19 86.00 High High
Aging 44 78.68 Quite High
Fibrosis 70 75.44 Quite High
Hantavirus Infection 3 74.00 Quite High
Syndrome 3 73.80 Quite High
Internal Fibrosis 16 72.32 Quite High
Injury 10 68.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
79% (Fig. 7A; tending to result in decrease in collagen protein) and presumably the latter effect dominated to explain the observed age-dependent decrease in collagen protein (Fig. 7B).
Negative_regulation (decrease) of collagen protein
1) Confidence 0.05 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.06 Pain Relevance 0.04
Consistent with the observations from the Masson's trichrome stained sections, there was no age-dependent change in vimentin mRNA and protein (fibroblast marker; Fig. 7) and, in fact, there was a decrease in collagen protein as measured by Picro Sirius red (Fig. 7B).
Negative_regulation (decrease) of collagen protein in fibroblast
2) Confidence 0.05 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.08 Pain Relevance 0.04
production by purified T cells, and PFD had no effect on the suppressive properties of naturally occurring regulatory T cells [25] In addition, the antifibrotic effect of PFD may be mediated through inhibition of heat shock protein 47, a collagen-specific molecular chaperone, with a resultant reduction in collagen synthesis in lung fibrosis [26].


Negative_regulation (inhibition) of heat shock protein 47 in lung associated with fibrosis, shock and pulmonary fibrosis
3) Confidence 0.04 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.39 Pain Relevance 0.56
This showed that the density of collagen protein was higher in the SAN than in the atrial muscle as expected, and in both tissues, there was a significant age-dependent decrease in the density of collagen protein (Fig. 7C); this is consistent with the mRNA data (Fig. 7A).
Negative_regulation (decrease) of collagen protein in muscle
4) Confidence 0.03 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.09 Pain Relevance 0
79% (Fig. 7A; tending to result in decrease in collagen protein) and presumably the latter effect dominated to explain the observed age-dependent decrease in collagen protein (Fig. 7B).
Negative_regulation (decrease) of collagen protein
5) Confidence 0.03 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.06 Pain Relevance 0.05

General Comments

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