INT303895

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (NAA50) cytoplasm (NAA50)
Anatomy Link Frequency
sinus 1
Nav1 (Rattus norvegicus)
NAA50 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nav1.1 1 43.04 Quite Low
Action potential 29 37.96 Quite Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
action potential duration 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 9 97.34 Very High Very High Very High
Body Weight 1 55.04 Quite High
Obesity 3 50.00 Quite Low
Aging 11 27.00 Quite Low
Hypertrophy 6 5.00 Very Low Very Low Very Low
Fibrosis 5 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is a possibility, because blockade of INa can slow pacemaking and familial sick sinus syndrome has been linked to mutations in Nav1.5 (main ion channel responsible for INa), although paradoxically there is little or no INa and Nav1.5 in the centre of the SAN [2].
Nav1.5 Regulation (centre) of SAN in sinus associated with heart rate under development
1) Confidence 0.11 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.24 Pain Relevance 0

General Comments

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