INT303913

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.09
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYP2D6) small molecule metabolic process (CYP2D6) oxidoreductase activity (CYP2D6)
endoplasmic reticulum (CYP2D6)
CYP2D6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dextromethorphan 1 99.56 Very High Very High Very High
Duloxetine 134 99.38 Very High Very High Very High
depression 29 97.80 Very High Very High Very High
antidepressant 9 89.92 High High
noradrenaline 4 88.16 High High
Serotonin 4 87.44 High High
Neurotransmitter 2 84.00 Quite High
antagonist 14 80.52 Quite High
5HT 1 79.72 Quite High
fluoxetine 1 77.84 Quite High
Disease Link Frequency Relevance Heat
Depression 64 97.80 Very High Very High Very High
Disease 7 73.44 Quite High
Constipation 51 72.40 Quite High
Recurrence 44 58.24 Quite High
Pain 26 56.80 Quite High
Death 1 56.56 Quite High
Cv General 2 Under Development 1 56.16 Quite High
Volume Depletion And Dehydration 1 55.04 Quite High
Diarrhoea 5 53.92 Quite High
Delirium 1 50.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methylnaltrexone is a weak inhibitor of CYP450 2D6 in vitro; however, in vivo, it has not affected the metabolism of the CYP2D6 substrate dextromethorphan.
Neg (not) Regulation (affected) of Regulation (metabolism) of CYP2D6 associated with dextromethorphan
1) Confidence 0.37 Published 2010 Journal Core evidence Section Body Doc Link PMC2899781 Disease Relevance 0.61 Pain Relevance 0.51
Duloxetine is eliminated through hepatic metabolism involving CYP2D6 and CYP1A2.37

Duloxetine in acute treatment of major depression

Regulation (metabolism) of Regulation (involving) of CYP2D6 associated with depression and duloxetine
2) Confidence 0.33 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2846146 Disease Relevance 0.47 Pain Relevance 0.97

General Comments

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