INT303962

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Context Info
Confidence 0.80
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 5.20
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep) extracellular space (Lep) extracellular region (Lep)
intracellular (Lep) lipid metabolic process (Lep)
Anatomy Link Frequency
brain 1
NK cells 1
Lep (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 21 91.52 High High
chemokine 3 90.92 High High
cytokine 30 90.48 High High
ketamine 6 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 1036 100.00 Very High Very High Very High
Aging 744 99.84 Very High Very High Very High
Stress 105 97.40 Very High Very High Very High
INFLAMMATION 24 91.52 High High
Adhesions 2 82.36 Quite High
Diabetes Mellitus 31 74.52 Quite High
Myocardial Infarction 12 58.76 Quite High
Uremia 1 42.56 Quite Low
Frailty 1 30.72 Quite Low
Apoptosis 12 21.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Short-term leptin treatment at physiological level (1.0 nM) reconciled
                   the reduced phosphorylation of Akt and eNOS in young ob/ob, but
                   not the aging mice. 
Phosphorylation (phosphorylation) of leptin associated with aging
1) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.87 Pain Relevance 0
Similar to its effect on other stress signaling
                   molecules, short-term leptin treatment at physiological level (1.0 nM) removed
                   obesity-induced phosphorylation of I?
Phosphorylation (phosphorylation) of obesity-induced associated with stress and obesity
2) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.03 Pain Relevance 0
This is also in line
               with the finding that leptin directly stimulates p38 MAP kinase phosphorylation
                   [43],
                   [44]. 
Phosphorylation (phosphorylation) of leptin
3) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.87 Pain Relevance 0.09
The leptin-induced
               STAT-3 phosphorylation was found to be higher along with an upregulated hypothalamic
               expression of the Ob-R at 14 - 18 months of mouse age compared with 2 months of age
                   [41],
               indicating increased leptin sensitivity with aging in the mouse brain. 
Phosphorylation (phosphorylation) of leptin-induced in brain associated with aging
4) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.46 Pain Relevance 0
Our data revealed reduced p38 MAP kinase phosphorylation in aged and
               obese mice, while leptin effectively restored p38 phosphorylation in young
                   ob/ob but not aging mice. 
Phosphorylation (phosphorylation) of leptin associated with aging and obesity
5) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.70 Pain Relevance 0.05
Moreover, the leptin receptors can signal in NK cells, since leptin activates STAT3 phosphorylation in NK cells.
Phosphorylation (phosphorylation) of leptin in NK cells
6) Confidence 0.55 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.25 Pain Relevance 0.16
Leptin at 1.0
                   nM reconciled the reduced ERK phosphorylation in aging ob/ob
                   mice without affecting any other mouse groups. 
Phosphorylation (phosphorylation) of Leptin associated with aging
7) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.03 Pain Relevance 0

General Comments

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