INT30397

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Context Info
Confidence 0.31
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.44
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (DNM2) GTPase activity (DNM2) cytoplasm (DNM2)
cytosol (DNM2) signal transduction (DNM2) nucleus (DNM2)
Anatomy Link Frequency
nerve 1
DNM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 9 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
Inflammation 2 99.40 Very High Very High Very High
Traumatic nerve injury 1 98.12 Very High Very High Very High
Substantia nigra 2 78.52 Quite High
antagonist 1 75.00 Quite High
Pain 5 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 99.40 Very High Very High Very High
Infection 208 98.52 Very High Very High Very High
Nervous System Injury 1 97.72 Very High Very High Very High
Targeted Disruption 8 71.72 Quite High
Dengue 22 71.20 Quite High
Apoptosis 9 57.20 Quite High
Togavirus Infection 23 56.32 Quite High
Viral Meningitis 10 33.80 Quite Low
Disease 17 30.44 Quite Low
Hepatocellular Cancer 2 15.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monoclonal antibodies specific for the cellular proteins, CLTC (Sigma Aldrich), AP2B1 (Abcam), DNM2 (Sigma Aldrich), ARRB1 (Abnova), ATP6V0A1 (Sigma Aldrich) and ARPC1B (Santa Cruz Biotechnology) were used for Western detection.
Positive_regulation (used) of DNM2
1) Confidence 0.31 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.08 Pain Relevance 0
Viral replication is blocked by compounds inhibiting endosomal acidification and likely requires the clathrin machinery, as demonstrated by the requirement of Dyn-2 for viral replication.
Positive_regulation (requirement) of Dyn-2
2) Confidence 0.28 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904475 Disease Relevance 0.36 Pain Relevance 0
It can be observed that at least one of the four siRNAs directed against each specific gene (CLTC, AP2B1, DNM2, ARRB1, ATP6V0A1 and ARPC1B) can result in more than 50% inhibition of DENV infection (Figure 3G) hence indicating the specificity of these genes in mediating DENV infection.
Positive_regulation (result) of DNM2 associated with infection
3) Confidence 0.15 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.80 Pain Relevance 0
The HAc extract contained much higher levels of ir-dyn B as compared to the MeOH/HCl extract, but approximately the same levels of ir-dyn A.
Positive_regulation (levels) of dyn B
4) Confidence 0.09 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2865698 Disease Relevance 0 Pain Relevance 0.42
PURPOSE: To identify possible targets that mediate the non-opioid effects of dynorphin-A (DynA), effects that include inflammation and aggravation of traumatic nerve injury.
Spec (possible) Positive_regulation (mediate) of DynA in nerve associated with nervous system injury, inflammation, dynorphin, traumatic nerve injury and opioid
5) Confidence 0.08 Published 1997 Journal Pharm. Res. Section Abstract Doc Link 9210186 Disease Relevance 0.20 Pain Relevance 0.37

General Comments

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