INT303972

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Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.30
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (JAK2) cytosol (JAK2) signal transduction (JAK2)
histone binding (JAK2) cytoskeleton (JAK2) nucleus (JAK2)
Anatomy Link Frequency
macrophages 2
JAK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 85.68 High High
chemokine 4 74.88 Quite High
cytokine 26 72.12 Quite High
Chronic pancreatitis 9 68.16 Quite High
Inflammation 31 54.52 Quite High
Inflammatory stimuli 2 37.60 Quite Low
Bile 1 20.32 Low Low
fibrosis 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 31 99.84 Very High Very High Very High
Adenocarcinoma 12 99.56 Very High Very High Very High
Cancer 48 99.36 Very High Very High Very High
Chronic Myeloid Leukemia 1 95.40 Very High Very High Very High
Myelodysplastic Syndromes 1 94.08 High High
Myeloproliferative Disorder 1 93.04 High High
Apoptosis 6 85.52 High High
Pancreatic Cancer 11 69.04 Quite High
Pancreatitis 9 68.16 Quite High
Fibrosis 6 66.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore the role of JAK2 overexpression in PSC of PDAC tumors remains to be functionally elucidated.
Positive_regulation (overexpression) of Gene_expression (overexpression) of JAK2 associated with adenocarcinoma, cancer and primary sclerosing cholangitis
1) Confidence 0.63 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.16 Pain Relevance 0.10
In addition, it accelerates cholesteryl ester accumulation in human monocyte-derived macrophages by increasing ACAT-1 expression via JAK2 and PI3K, thereby suppressing cholesterol efflux [29].
Positive_regulation (increasing) of Gene_expression (expression) of JAK2 in macrophages
2) Confidence 0.21 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.14 Pain Relevance 0.14

General Comments

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