INT303984

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.85
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lep, IL8) extracellular space (Lep, IL8) extracellular region (Lep, IL8)
intracellular (Lep, IL8) lipid metabolic process (Lep)
Lep (Mus musculus)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 48 91.28 High High
spinal inflammation 2 87.44 High High
Inflammation 18 84.88 Quite High
antagonist 2 32.08 Quite Low
chemokine 6 21.28 Low Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
endometriosis 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 4 93.36 High High
Low Back Pain 2 87.44 High High
INFLAMMATION 24 84.88 Quite High
Stress 6 77.68 Quite High
Osteoarthritis 2 76.32 Quite High
Apoptosis 12 59.52 Quite High
Obesity 44 56.96 Quite High
Body Weight 2 11.20 Low Low
Autoimmune Disease 6 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, leptin has also been found to increase the production of IL-8, IL-12, IL-6, and TNF-?
leptin Positive_regulation (increase) of Gene_expression (production) of IL-8
1) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.29 Pain Relevance 0.04
In addition, leptin alone or in combination with IL-1 enhanced the expression of iNOS and COX-2 and production of NO, PGE (2), IL-6, and IL-8.
leptin Positive_regulation (enhanced) of Gene_expression (production) of IL-8
2) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.56 Pain Relevance 0.23

General Comments

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