INT303992

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.55 Pain Relevance 0.23

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8) intracellular (IL8)

Il1 (Mus musculus) IL8 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 24 89.84 spinal inflammation 1 86.00 Inflammation 9 66.84 chemokine 3 5.00 Inflammatory stimuli 2 5.00 withdrawal 1 5.00 endometriosis 1 5.00 Inflammatory response 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Cancer 2 91.92 Low Back Pain 1 86.00 Osteoarthritis 1 76.32 INFLAMMATION 12 66.84 Stress 3 60.72 Apoptosis 6 59.52 Obesity 22 55.52 Body Weight 1 11.20 Autoimmune Disease 3 5.00 Adhesions 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, leptin alone or in combination with IL-1 enhanced the expression of iNOS and COX-2 and production of NO, PGE (2), IL-6, and IL-8.

IL-1 Positive_regulation (enhanced) of Gene_expression (production) of IL-8

1) Confidence 0.00 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.55 Pain Relevance 0.23

General Comments

This test has worked.