INT304012

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AKT1, PIK3CA) signal transduction (AKT1, PIK3CA) cell differentiation (AKT1)
nucleoplasm (AKT1) transport (AKT1) small molecule metabolic process (AKT1)
AKT1 (Homo sapiens)
PIK3CA (Homo sapiens)
AKT1 - E17K (1)
Pain Link Frequency Relevance Heat
metalloproteinase 2 5.00 Very Low Very Low Very Low
pain pelvic 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 36 97.80 Very High Very High Very High
Endometrial Cancer 306 94.00 High High
Apoptosis 32 77.08 Quite High
Adenocarcinoma 12 75.04 Quite High
Endometroid Carcinoma 42 72.24 Quite High
Cancer 170 55.84 Quite High
Carcinoma 122 50.08 Quite High
Microsatellite Instability 94 19.92 Low Low
Hyperplasia 36 5.64 Low Low
Endometrial Stromal Sarcoma 78 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AKT1 E17K mutation is not associated with either PTEN or PIK3CA genomic alteration [21].
AKT1 (E17K) Binding (associated) of PIK3CA
1) Confidence 0.28 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.46 Pain Relevance 0
Recently, interactions between the PI3K/AKT and p53 signaling pathways have been described in which activation of the PI3K/AKT pathway through PTEN or PIK3CA mutations, together with p53 inactivation, results in malignant transformation [15].
AKT Binding (interactions) of PIK3CA associated with malignant neoplastic disease
2) Confidence 0.25 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.67 Pain Relevance 0

General Comments

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