INT304024

Context Info Confidence 0.33 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.08 Pain Relevance 0

nucleus (AKT1, PTEN) plasma membrane (AKT1, PTEN) enzyme binding (AKT1, PTEN) cytoplasm (AKT1, PTEN) cytosol (AKT1, PTEN) cell proliferation (AKT1, PTEN)

AKT1 (Homo sapiens) PTEN (Homo sapiens) AKT1 - E17K (1)

Pain Link Frequency Relevance Heat metalloproteinase 2 5.00 pain pelvic 2 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Malignant Neoplastic Disease 36 97.40 Endometrial Cancer 306 94.00 Apoptosis 32 77.08 Adenocarcinoma 12 74.24 Endometroid Carcinoma 42 71.44 Cancer 170 55.04 Carcinoma 122 49.28 Microsatellite Instability 94 19.92 Hyperplasia 36 5.64 Endometrial Stromal Sarcoma 78 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

AKT1 E17K mutation is not associated with either PTEN or PIK3CA genomic alteration [21].

AKT1 (E17K) Binding (associated) of PTEN

1) Confidence 0.33 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.46 Pain Relevance 0

Recently, interactions between the PI3K/AKT and p53 signaling pathways have been described in which activation of the PI3K/AKT pathway through PTEN or PIK3CA mutations, together with p53 inactivation, results in malignant transformation [15].

AKT Binding (interactions) of PTEN associated with malignant neoplastic disease

2) Confidence 0.29 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.62 Pain Relevance 0

General Comments

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