INT304027

Context Info Confidence 0.32 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.86 Pain Relevance 0

enzyme binding (PTEN, AKT1) cytoplasm (PTEN, AKT1) cytosol (PTEN, AKT1) cell proliferation (PTEN, AKT1) nucleus (PTEN, AKT1) plasma membrane (PTEN, AKT1)

PTEN (Homo sapiens) AKT1 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 1 5.00 pain pelvic 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 16 99.16 Adenocarcinoma 6 94.04 Endometrial Hyperplasia 4 93.32 Endometrial Cancer 153 90.72 Necrosis 1 80.40 Cancer 85 80.04 Death 2 79.08 Congenital Anomalies 2 67.52 Carcinoma 61 61.64 Endometroid Carcinoma 21 50.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, loss of PTEN function leads to increased levels of phospho-AKT, activation of anti-apoptotic protein, and cell cycle progression [9].

Negative_regulation (loss) of PTEN Positive_regulation (leads) of Positive_regulation (increased) of AKT associated with apoptosis

1) Confidence 0.32 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.86 Pain Relevance 0

General Comments

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