INT304029

Context Info Confidence 0.35 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.62 Pain Relevance 0

nucleus (PTEN, TP53) enzyme binding (PTEN, TP53) cytoplasm (PTEN, TP53) cell proliferation (PTEN, TP53) cytosol (PTEN, TP53) cell differentiation (TP53)

PTEN (Homo sapiens) TP53 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 1 5.00 pain pelvic 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Malignant Neoplastic Disease 18 97.40 Adenocarcinoma 6 74.24 Endometrial Cancer 153 72.68 Endometroid Carcinoma 21 71.44 Apoptosis 16 55.76 Cancer 85 55.04 Carcinoma 61 49.28 Microsatellite Instability 47 5.00 Endometrial Stromal Sarcoma 39 5.00 Carcinosarcoma 29 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recently, interactions between the PI3K/AKT and p53 signaling pathways have been described in which activation of the PI3K/AKT pathway through PTEN or PIK3CA mutations, together with p53 inactivation, results in malignant transformation [15].

PTEN Binding (interactions) of p53 associated with malignant neoplastic disease

1) Confidence 0.35 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.62 Pain Relevance 0

General Comments

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