INT304050

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Context Info
Confidence 0.54
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 6.53
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SUZ12) intracellular (SUZ12)
Anatomy Link Frequency
stroma 2
nodule 1
SUZ12 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 6 5.00 Very Low Very Low Very Low
pain pelvic 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometrial Stromal Sarcoma 234 99.44 Very High Very High Very High
Endometrial Stromal Tumors 42 98.56 Very High Very High Very High
Sarcoma 138 96.92 Very High Very High Very High
Malignant Neoplastic Disease 108 96.88 Very High Very High Very High
Cancer 510 93.04 High High
Carcinoma 366 90.40 High High
Endometroid Carcinoma 126 89.56 High High
Muscle Neoplasms 12 80.72 Quite High
Chromosome Aberrations 12 70.56 Quite High
Endometrial Cancer 918 67.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The JAZF1/JJAZ1 fusion gene is frequently present in classical endometrial stromal sarcomas and less often in cases with variant histology [46].
Gene_expression (present) of JJAZ1 associated with endometrial stromal sarcoma
1) Confidence 0.54 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.08 Pain Relevance 0
Although JAZF1/JJAZ1 fusion may not be universally present in all low grade endometrial stromal sarcoma, this aberration may still be diagnostically useful [44].
Neg (not) Gene_expression (present) of JJAZ1 associated with endometrial stromal sarcoma
2) Confidence 0.54 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.84 Pain Relevance 0
JAZF1 is expressed in normal endometrial stroma, but the specific functions of the JAZF1 and the JJAZ1 genes as well as the JAZF1/JJAZ1 fusion gene are still unknown [1, 42].
Gene_expression (functions) of JJAZ1 in stroma
3) Confidence 0.54 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.04 Pain Relevance 0
JAZF1 is expressed in normal endometrial stroma, but the specific functions of the JAZF1 and the JJAZ1 genes as well as the JAZF1/JJAZ1 fusion gene are still unknown [1, 42].
Gene_expression (functions) of JJAZ1 in stroma
4) Confidence 0.54 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.02 Pain Relevance 0
The distinct molecular alteration described in the majority of endometrial stromal sarcomas is the t(7;17)(p15;q21) leading to the formation of fusion gene JAZF1/JJAZ1, which can be detected by RT-PCR or FISH assays.
Gene_expression (detected) of JJAZ1 associated with endometrial stromal sarcoma
5) Confidence 0.48 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.51 Pain Relevance 0
The presence of the JAZF1/JJAZ1 fusion gene within the spectrum of endometrial stromal tumors from benign to malignant raises possibility that the endometrial stromal nodule may transform into malignant endometrial stromal sarcoma [41, 47].
Gene_expression (presence) of JJAZ1 in nodule associated with endometrial stromal sarcoma, malignant neoplastic disease and endometrial stromal tumors
6) Confidence 0.48 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.05 Pain Relevance 0

General Comments

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