INT304058

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (MSI1) nucleus (MSI1) cytoplasm (MSI1)
Anatomy Link Frequency
MLH1 1
MSI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 2 5.00 Very Low Very Low Very Low
pain pelvic 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microsatellite Instability 94 100.00 Very High Very High Very High
Endometrial Cancer 306 99.74 Very High Very High Very High
Cancer 170 98.88 Very High Very High Very High
Carcinoma 122 97.88 Very High Very High Very High
Hyperplasia 36 86.16 High High
Endometroid Carcinoma 42 48.00 Quite Low
Colon Cancer 16 21.20 Low Low
Metaplasia 6 8.76 Low Low
Endometrial Hyperplasia 8 7.76 Low Low
Endometrial Stromal Sarcoma 78 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, MSH6 mutations seem to be a frequent cause of MSI [11, 12].
Positive_regulation (cause) of MSI associated with microsatellite instability
1) Confidence 0.07 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.33 Pain Relevance 0
In sporadic endometrial carcinoma, epigenetic cause of MSI is more common involving MLH1 promotor hypermethylation which is the main cause of MMR deficiency [7–9, 13, 15].
Positive_regulation (cause) of MSI in MLH1 associated with microsatellite instability and endometrial cancer
2) Confidence 0.05 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.41 Pain Relevance 0

General Comments

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