INT304058

Context Info Confidence 0.07 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.74 Pain Relevance 0

RNA binding (MSI1) nucleus (MSI1) cytoplasm (MSI1)

Anatomy Link Frequency MLH1 1 MSI1 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 2 5.00 pain pelvic 2 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Microsatellite Instability 94 100.00 Endometrial Cancer 306 99.74 Cancer 170 98.88 Carcinoma 122 97.88 Hyperplasia 36 86.16 Endometroid Carcinoma 42 48.00 Colon Cancer 16 21.20 Metaplasia 6 8.76 Endometrial Hyperplasia 8 7.76 Endometrial Stromal Sarcoma 78 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, MSH6 mutations seem to be a frequent cause of MSI [11, 12].

Positive_regulation (cause) of MSI associated with microsatellite instability

1) Confidence 0.07 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.33 Pain Relevance 0

In sporadic endometrial carcinoma, epigenetic cause of MSI is more common involving MLH1 promotor hypermethylation which is the main cause of MMR deficiency [7–9, 13, 15].

Positive_regulation (cause) of MSI in MLH1 associated with microsatellite instability and endometrial cancer

2) Confidence 0.05 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.41 Pain Relevance 0

General Comments

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