INT304060

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Context Info
Confidence 0.70
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 17
Disease Relevance 13.00
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (AGR2) extracellular region (AGR2) endoplasmic reticulum (AGR2)
Anatomy Link Frequency
anterior 2
plasma 1
CFPAC-1 1
ducts 1
AGR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 80 99.88 Very High Very High Very High
imagery 16 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 192 99.88 Very High Very High Very High
Pancreatic Cancer 752 99.60 Very High Very High Very High
Endometrial Cancer 153 99.32 Very High Very High Very High
Cancer 437 99.28 Very High Very High Very High
Malignant Neoplastic Disease 178 99.12 Very High Very High Very High
Ovarian Cancer 16 98.80 Very High Very High Very High
Disease 135 98.24 Very High Very High Very High
Apoptosis 16 79.24 Quite High
Congenital Anomalies 2 72.28 Quite High
Adenocarcinoma 54 70.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the elevation of AGR2 level in the pancreatic juice was correlated with high expression in PanIN ducts.
Positive_regulation (elevation) of AGR2 in ducts
1) Confidence 0.70 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.44 Pain Relevance 0
The pancreatic juice AGR2 level was significantly elevated in patients with premalignant lesions and pancreatic cancer compared to control samples.
Positive_regulation (elevated) of AGR2 associated with pancreatic cancer
2) Confidence 0.61 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.86 Pain Relevance 0.06
In this study, we found that AGR2 was significantly elevated in the pancreatic juice from patients with pre-malignant conditions (PanINs and IPMNs) as well as pancreatic cancer compared to control pancreatic juice samples.
Positive_regulation (elevated) of AGR2 associated with malignant neoplastic disease and pancreatic cancer
3) Confidence 0.47 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.85 Pain Relevance 0.07
Moreover, when we compared sera from pancreatic cancer cases and cancer-free controls, only 1/9 pancreatic cancer sera showed a high level of AGR2, compared to 0/9 cancer-free controls.
Positive_regulation (level) of AGR2 associated with cancer and pancreatic cancer
4) Confidence 0.47 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.78 Pain Relevance 0
Among the differential proteins revealed, AGR2 was elevated in all PanIN3 juice samples analyzed.
Positive_regulation (elevated) of AGR2
5) Confidence 0.47 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.89 Pain Relevance 0.05
AGR2 levels in the pancreatic juice samples were found significantly elevated in patients with pre-malignant conditions (PanINs and IPMNs) as well as pancreatic cancer compared to control samples (p ?
Positive_regulation (elevated) of AGR2 associated with malignant neoplastic disease and pancreatic cancer
6) Confidence 0.47 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2893103 Disease Relevance 1.18 Pain Relevance 0.10
As expected, the ELISA detected higher levels of AGR2 protein in lysates from CFPAC-1 cells (120.7 ng/ml) compared to MiaPaca cells (14.6 ng/ml) (Table 4).
Positive_regulation (levels) of AGR2 protein in CFPAC-1
7) Confidence 0.47 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.15 Pain Relevance 0
One recent study showed that increased AGR2 in plasma is associated with ovarian cancer[26].
Positive_regulation (increased) of AGR2 in plasma associated with ovarian cancer
8) Confidence 0.47 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.91 Pain Relevance 0
Significant elevation of AGR2 levels in the pancreatic juice samples from patients with pre-malignant pancreatic neoplasia
Positive_regulation (elevation) of AGR2 associated with malignant neoplastic disease and pancreatic cancer
9) Confidence 0.47 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 1.01 Pain Relevance 0.08
We found that AGR2 was elevated in all of the three pre-neoplastic pancreatic juice samples (PanIN3) analyzed by quantitative proteomics.
Positive_regulation (elevated) of AGR2
10) Confidence 0.47 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.72 Pain Relevance 0
The discovery of AGR2 elevation in the pancreatic juice of PanIN3 patients in this study may provide a future opportunity to develop and test this candidate as juice biomarker for PanIN3.
Positive_regulation (elevation) of AGR2
11) Confidence 0.47 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.92 Pain Relevance 0.09
These results suggest that elevation of AGR2 levels in pancreatic juice occurs in early pancreatic cancer progression and could be further investigated as a potential candidate juice biomarker for early detection of pancreatic cancer.



Positive_regulation (elevation) of AGR2 associated with pancreatic cancer
12) Confidence 0.47 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2893103 Disease Relevance 1.17 Pain Relevance 0.08
By Western blot, mAb AGR2.43 detected the 45 kDa GST-tagged rAGR2, but not GST-tagged rAGR3 protein (Figure 2).
Neg (not) Positive_regulation (tagged) of rAGR2
13) Confidence 0.44 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.33 Pain Relevance 0
Among these elevated proteins, anterior gradient-2 (AGR2) was elevated by 10.47 ± 0.01; 3.96 ± 0.03; and 2.04 ± 0.01 folds in the three PanIN3 pancreatic juice samples respectively, comparing to the pooled control sample (Figure 1).
Positive_regulation (elevated) of anterior gradient-2 in anterior
14) Confidence 0.41 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.22 Pain Relevance 0
While AGR2 levels were significantly elevated in the pancreatic juice from premalignant and pancreatic cancer patients, serum levels of AGR2 did not distinguish patients with premalignant or pancreatic cancer from control patients.
Positive_regulation (elevated) of AGR2 associated with pancreatic cancer
15) Confidence 0.41 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 1.02 Pain Relevance 0.09
Among these elevated proteins, anterior gradient-2 (AGR2) was elevated by 10.47 ± 0.01; 3.96 ± 0.03; and 2.04 ± 0.01 folds in the three PanIN3 pancreatic juice samples respectively, comparing to the pooled control sample (Figure 1).
Positive_regulation (elevated) of AGR2 in anterior
16) Confidence 0.41 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.22 Pain Relevance 0
Intestinal trefoil protein, TFF3, AGR2 developmental gene, estrogen-regulated genes (MGB2, LTF, END1, MMP11), FOXA2, and MSX2 were significantly up-regulated in endometrioid endometrial carcinomas, while increased expression of FOLR, genes involved in the regulation of mitotic spindle checkpoint (STK15, BUB1, CCNB2), IGF2, PTGS1 and p16 were seen in non-endometrioid endometrial carcinomas.
Positive_regulation (regulated) of AGR2 associated with endometrial cancer
17) Confidence 0.08 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.33 Pain Relevance 0

General Comments

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