INT304076

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (KRAS) mitochondrion (KRAS) plasma membrane (KRAS)
GTPase activity (KRAS)
KRAS (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 30.08 Quite Low
Bile 6 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 109 99.64 Very High Very High Very High
Cholangiocarcinoma 74 99.12 Very High Very High Very High
Endometrial Cancer 153 96.56 Very High Very High Very High
Carcinoma 67 81.20 Quite High
Colorectal Cancer 9 74.24 Quite High
Carcinosarcoma 29 73.28 Quite High
Sarcoma 24 57.04 Quite High
Disease 8 51.36 Quite High
Metastasis 6 50.60 Quite High
Apoptosis 30 12.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They are associated with a number of well-described genetic alterations including mutations of PTEN, KRAS, ?
Regulation (alterations) of Localization (mutations) of KRAS
1) Confidence 0.36 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.29 Pain Relevance 0
One of them is that KRAS mutations should be examined in the clinical trials on the effect of EGFR blockade in this tumor type.
Spec (examined) Regulation (effect) of Localization (blockade) of KRAS associated with cancer
2) Confidence 0.33 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 1.10 Pain Relevance 0

General Comments

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