INT304079

Context Info Confidence 0.27 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.20 Pain Relevance 0

mitochondrion (AGR2) extracellular region (AGR2) endoplasmic reticulum (AGR2)

AGR2 (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic pancreatitis 5 5.00 metalloproteinase 1 5.00 pain pelvic 1 5.00 imagery 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Endometrial Cancer 153 97.04 Apoptosis 16 79.24 Congenital Anomalies 2 72.28 Aneuploidy 3 57.60 Malignant Neoplastic Disease 28 56.32 Pancreatic Cancer 47 49.68 Adenocarcinoma 9 46.20 Endometrial Hyperplasia 4 45.48 Microsatellite Instability 47 33.92 Necrosis 1 32.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To assess the effects of serum on the AGR2 ELISA, we added 10% Normal Human Serum (NHS) to a subset of samples.

Regulation (effects) of AGR2

1) Confidence 0.27 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0 Pain Relevance 0

Intestinal trefoil protein, TFF3, AGR2 developmental gene, estrogen-regulated genes (MGB2, LTF, END1, MMP11), FOXA2, and MSX2 were significantly up-regulated in endometrioid endometrial carcinomas, while increased expression of FOLR, genes involved in the regulation of mitotic spindle checkpoint (STK15, BUB1, CCNB2), IGF2, PTGS1 and p16 were seen in non-endometrioid endometrial carcinomas.

Regulation (regulated) of AGR2 associated with endometrial cancer

2) Confidence 0.11 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.20 Pain Relevance 0

General Comments

This test has worked.