INT304099

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.13
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il13) extracellular region (Il13) cytoplasm (Il13)
Anatomy Link Frequency
sputum 1
IGHE (Homo sapiens)
Il13 (Mus musculus)
Il13 - R110Q (1)
Pain Link Frequency Relevance Heat
Inflammation 42 91.80 High High
antagonist 3 74.16 Quite High
aspirin 24 54.40 Quite High
cytokine 6 32.52 Quite Low
cINOD 6 11.60 Low Low
Disease Link Frequency Relevance Heat
Asthma 246 99.52 Very High Very High Very High
Eczema 3 98.84 Very High Very High Very High
Hypersensitivity 12 95.32 Very High Very High Very High
Rhinitis 57 92.60 High High
INFLAMMATION 45 91.80 High High
Chronic Sinusitis 12 64.32 Quite High
Urticaria 3 55.56 Quite High
Adhesions 3 54.48 Quite High
Occupational Lung Diseases 6 48.28 Quite Low
Eosinophilia 9 38.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This SNP was also reported to be associated with methacholine AHR and asthma development in a childhood asthma cohort based on a Korean population.21 Specifically, IL-13 110AA was associated with increased total IgE levels and asthma development in children.
IgE Binding (associated) of IL-13 associated with asthma
1) Confidence 0.17 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.37 Pain Relevance 0.07
In ethnic German populations, the IL-13 Arg110Gln variant has a significant association with high IgE levels.13 In addition, this allele was associated with the asthma phenotype in British and Japanese populations.14 Moreover, IL-13 is necessary and sufficient for the induction of AHR eosinophilic airway inflammation; in the absence of IL-13, this does not progress to AHR.
IgE Binding (association) of IL-13 (R110Q) associated with asthma, rhinitis and inflammation
2) Confidence 0.13 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.21 Pain Relevance 0.08
Recently, polymorphisms in IL-13 have been associated with the serum total IgE and eosinophil count and may be associated with asthma exacerbations.20 However, we did not find any significant result in terms of the IL-13 gene polymorphism and sputum eosinophil count in our study.
IgE Binding (associated) of IL-13 in sputum associated with asthma
3) Confidence 0.13 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.54 Pain Relevance 0.23

General Comments

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