INT304101

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.69
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il13, CCL11) extracellular region (Il13, CCL11) signal transduction (CCL11)
cell adhesion (CCL11) cytoskeleton organization (CCL11) cytoplasm (Il13)
Anatomy Link Frequency
lung 1
Il13 (Mus musculus)
CCL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 81.72 Quite High
aspirin 8 50.00 Quite Low
cytokine 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 99.60 Very High Very High Very High
Occupational Lung Diseases 2 94.28 High High
Asthma 82 85.36 High High
Rhinitis 19 82.24 Quite High
INFLAMMATION 15 81.72 Quite High
Chronic Sinusitis 4 37.68 Quite Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Eosinophilia 3 5.00 Very Low Very Low Very Low
Nasal Polyps 2 5.00 Very Low Very Low Very Low
Eczema 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-13 is reported to induce eosinophil recruitment into the lung via an IL-5- and eotaxin-dependent mechanism.30 Indeed, several studies have reported that IL-13 induces eotaxin production in epithelial and smooth muscle cells.31,32 In-vivo data have shown that IL-13 stimulates eotaxin in IL-13 transgenic mice.33 The increase in eotaxin-1 levels was proportional to the impaired lung function and bronchial hyper-reactivity in asthmatics, as shown in previous studies.34,35 In this study, we found that the GG genotype of the Arg110Gln (110G>A) polymorphism was associated with a significantly higher eotaxin-1 level, as compared to the AA type; these findings suggest that the 110G allele is associated with eotaxin-1-mediated eosinophilic inflammation.
IL-13 Positive_regulation (stimulates) of eotaxin in lung associated with targeted disruption, rhinitis, inflammation and occupational lung diseases
1) Confidence 0.43 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 0.69 Pain Relevance 0.04

General Comments

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