INT304136

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.70
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Fip1l1) RNA binding (Fip1l1) nucleus (Fip1l1)
Fip1l1 (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 5 93.96 High High
cytokine 24 44.00 Quite Low
Inflammation 17 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypereosinophilic Syndrome 17 99.48 Very High Very High Very High
Disease 20 98.96 Very High Very High Very High
Eosinophilia 16 97.76 Very High Very High Very High
Rhinitis 11 77.40 Quite High
Leukocytosis 1 75.48 Quite High
Targeted Disruption 8 72.52 Quite High
Chronic Myeloid Leukemia 1 58.84 Quite High
Cancer 3 56.56 Quite High
Necrosis 3 56.08 Quite High
Apoptosis 77 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that FIP1L1-PDGFRA fusion gene is not sufficient to induce a HES/CEL-like disease but requires a second event associated with IL-5 overexpression.75 Finally, treatment with mepolizumab can result in corticosteroid-sparing for patients negative for FIP1L1-PDGFRA who have the hypereosinophilic syndrome.76


PATHWAYS FOR MAINTAINING EOSINOPHIL SURVIVAL

Neg (not) Positive_regulation (sufficient) of FIP1L1-PDGFRA associated with corticosteroid, hypereosinophilic syndrome and disease
1) Confidence 0.24 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 1.70 Pain Relevance 0.05

General Comments

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