INT304141

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Epx)
Anatomy Link Frequency
T cells 2
Epx (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 24 5.00 Very Low Very Low Very Low
Inflammation 17 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Common Cold 1 99.96 Very High Very High Very High
Respiratory Syncytial Virus 4 99.64 Very High Very High Very High
Parainfluenza Virus Infection 1 98.84 Very High Very High Very High
Helminth Infection 2 71.12 Quite High
Infection 7 65.00 Quite High
Pneumonia 1 56.88 Quite High
Apoptosis 77 50.00 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 18.64 Low Low
Toxicity 1 16.24 Low Low
Fungal Infection 1 10.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eosinophil granule proteins are known for their ribonuclease activity (such as human eosinophil cationic protein (ECP, RNase 3) and eosinophil-derived neurotoxin (EDN, RNase 2), and at least 11 eosinophil associated ribonucleases (EAR) orthologs in mice) and have been shown to degrade single-stranded RNA-containing viruses.25 Interestingly, it has recently been shown that viruses (parainfluenza virus, respiratory syncytial virus (RSV), or rhinovirus) induce the release of eosinophil peroxidase (EPO) by eosinophils when co-incubated in the presence of antigen-presenting cells and T cells.26 In fact, ECP and EDN are the most divergent coding sequences in the entire human genome (compared with other primates).25 Despite their divergence, they have conserved ribonuclease activity across species, strongly implicating evolutionary pressure to preserve this critical enzymatic activity.
Positive_regulation (induce) of Localization (release) of EPO in T cells associated with common cold, parainfluenza virus infection and respiratory syncytial virus
1) Confidence 0.22 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.72 Pain Relevance 0

General Comments

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