INT304149

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.81
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il5) extracellular region (Il5)
Anatomy Link Frequency
eosinophil 2
Il5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 24 99.66 Very High Very High Very High
Inflammation 17 62.28 Quite High
chemokine 4 15.56 Low Low
corticosteroid 5 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eosinophilic Esophagitis 8 99.20 Very High Very High Very High
Eosinophilia 16 96.60 Very High Very High Very High
Celiac Disease 2 71.16 Quite High
Anaphylaxis 2 70.44 Quite High
Hypersensitivity 15 69.44 Quite High
Malignant Neoplastic Disease 1 66.40 Quite High
Parasitic Infection 3 65.92 Quite High
INFLAMMATION 16 62.28 Quite High
Disease 20 62.24 Quite High
Colitis 2 58.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A minimum of 15 eosinophils per high power field is now used as pathological criteria for EE.64 Murine models have demonstrated that IL-5 maintains the systemic eosinophil levels needed for esophageal eosinophilia accumulation.16 Substantial evidence is accumulating that human EE is also associated with a Th2 type immune response and local or systemic Th2 cytokine overproduction; IL-5 mRNA expression is induced in the biopsies of EE patients compared to healthy controls,65 and anti-IL-5 may be effective in some but not all patients with EE.66, 67 In human EE, eotaxin-3 (CCL26) expression strongly correlates with eosinophil numbers.68
Positive_regulation (induced) of Transcription (expression) of IL-5 in eosinophil associated with eosinophilia, eosinophilic esophagitis and cytokine
1) Confidence 0.09 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 1.81 Pain Relevance 0.08

General Comments

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