INT304168

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Gata1, Sfpi1) DNA binding (Gata1, Sfpi1) RNA binding (Sfpi1)
nucleolus (Gata1) cell-cell signaling (Gata1)
Anatomy Link Frequency
eosinophil 1
Gata1 (Mus musculus)
Sfpi1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 24 46.96 Quite Low
Inflammation 17 36.92 Quite Low
corticosteroid 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rhinitis 11 72.84 Quite High
Apoptosis 77 50.00 Quite Low
INFLAMMATION 16 36.92 Quite Low
Disease 20 21.04 Low Low
Hypersensitivity 15 20.68 Low Low
Asthma 24 5.00 Very Low Very Low Very Low
Death 22 5.00 Very Low Very Low Very Low
Hypereosinophilic Syndrome 17 5.00 Very Low Very Low Very Low
Eosinophilia 16 5.00 Very Low Very Low Very Low
Eczema 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, high levels of PU.1 lead to an increase in myeloid differentiation.3 In most cells, PU.1 antagonizes GATA-1 (a zinc finger family member), the latter of which has synergistic activity in regulating eosinophil lineage specification and eosinophil granule protein transcription.4 The interferon consensus sequence binding protein (ICSBP) is also a key transcription factor for eosinophils and is demonstrated by a loss of eosinophils in ICSBP-deficient mice.5 Of these transcription factors, GATA-1 is clearly the most important for eosinophil lineage specification, based on loss of the eosinophil lineage in mice harboring a targeted deletion of the high affinity GATA-binding site in the GATA-1 promoter,6 and based on eosinophil differentiation experiments in vitro.7
GATA-1 Binding (antagonizes) of PU.1 in eosinophil
1) Confidence 0.08 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.07 Pain Relevance 0

General Comments

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