INT30423

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Context Info
Confidence 0.26
First Reported 1985
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 0.77
Pain Relevance 4.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk, Ins1) extracellular space (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
pancreas 4
Penk (Rattus norvegicus)
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 33 100.00 Very High Very High Very High
narcan 24 100.00 Very High Very High Very High
Somatostatin 15 100.00 Very High Very High Very High
opiate 2 100.00 Very High Very High Very High
antagonist 2 100.00 Very High Very High Very High
Morphine 5 96.16 Very High Very High Very High
Opioid 1 75.00 Quite High
opioid receptor 3 33.56 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 12 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since little is known about the effect of Leu-Enk on insulin and glucagon secretion, it was the aim of this study to determine the role of Leu-Enk on insulin and glucagon secretion from the isolated pancreatic tissue fragments of normal and diabetic rats.
Leu-Enk Regulation (effect) of Localization (secretion) of insulin associated with diabetes mellitus
1) Confidence 0.26 Published 2001 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 11880925 Disease Relevance 0.25 Pain Relevance 0.20
The effect of met-enkephalin and the opiate antagonist, naloxone, on somatostatin and insulin secretion from the isolated, perfused rat pancreas has been studied during perfusion with 300 mg/dl glucose.
met-enkephalin Regulation (effect) of Localization (secretion) of insulin in pancreas associated with antagonist, somatostatin, narcan, opiate and enkephalin
2) Confidence 0.20 Published 1985 Journal Diabetes Section Abstract Doc Link 2866128 Disease Relevance 0 Pain Relevance 0.85
The effect of met-enkephalin and naloxone on somatostatin and insulin secretion from the isolated, perfused rat pancreas.
met-enkephalin Regulation (effect) of Localization (secretion) of insulin in pancreas associated with somatostatin, narcan and enkephalin
3) Confidence 0.20 Published 1985 Journal Diabetes Section Title Doc Link 2866128 Disease Relevance 0 Pain Relevance 1.14
The role of leucine-enkephalin on insulin and glucagon secretion from pancreatic tissue fragments of normal and diabetic rats.
leucine-enkephalin Regulation (role) of Localization (secretion) of insulin associated with diabetes mellitus, narcan and enkephalin
4) Confidence 0.19 Published 2001 Journal Arch. Physiol. Biochem. Section Title Doc Link 11880925 Disease Relevance 0.26 Pain Relevance 0.31
Since little is known about the effect of Leu-Enk on insulin and glucagon secretion, it was the aim of this study to determine the role of Leu-Enk on insulin and glucagon secretion from the isolated pancreatic tissue fragments of normal and diabetic rats.
Leu-Enk Regulation (role) of Localization (secretion) of insulin associated with diabetes mellitus
5) Confidence 0.19 Published 2001 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 11880925 Disease Relevance 0.26 Pain Relevance 0.20
Cysteamine pretreatment of rats (depletion of somatostatin containing D-cells and decrease in somatostatin secretion) did not change the Met-enkephalin effect on insulin secretion.
Met-enkephalin Regulation (effect) of Localization (secretion) of insulin associated with somatostatin and enkephalin
6) Confidence 0.10 Published 1986 Journal Biochim. Biophys. Acta Section Abstract Doc Link 2874836 Disease Relevance 0 Pain Relevance 1.71

General Comments

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