INT304340

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.71
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (FKBP5, NR3C1) nucleolus (FKBP5, NR3C1) nucleus (FKBP5, NR3C1)
nucleoplasm (NR3C1) isomerase activity (FKBP5) aging (NR3C1)
Anatomy Link Frequency
immune cells 1
FKBP5 (Homo sapiens)
NR3C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 6 92.24 High High
depression 39 88.36 High High
antidepressant 3 81.80 Quite High
Catecholamine 1 61.40 Quite High
Dopamine 1 53.68 Quite High
Neurotransmitter 2 52.00 Quite High
cytokine 1 44.52 Quite Low
amygdala 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 8 94.84 High High
Manic Depressive Disorder 2 89.20 High High
Depression 38 88.36 High High
Congenital Anomalies 3 77.48 Quite High
Disease Progression 1 74.80 Quite High
Disease 10 70.32 Quite High
Cognitive Disorder 1 26.76 Quite Low
Handedness 1 7.24 Low Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binder et al. [14] reported that polymorphisms in FKBP5, a glucocorticoid receptor–regulating co-chaperone of hsp90, are associated with increased lymphocytic levels of FKBP5 protein, as well as an altered response of the stress hormone system, suggesting that the functional effects of these polymorphisms were not limited to immune cells, but also affected CNS function.
FKBP5 Regulation (regulating) of glucocorticoid receptor in immune cells associated with stress and central nervous system
1) Confidence 0.05 Published 2010 Journal Curr Psychiatry Rep Section Body Doc Link PMC2847693 Disease Relevance 0.71 Pain Relevance 0.37

General Comments

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