INT304377

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle cell 1
muscle 1
MIR206 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 39 40.92 Quite Low
lidocaine 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
local anesthetic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 105 50.00 Quite Low
Impaired Glucose Tolerance 39 40.92 Quite Low
Diabetes Mellitus 237 32.16 Quite Low
Disease 51 5.00 Very Low Very Low Very Low
Obesity 21 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Hyperinsulinism 6 5.00 Very Low Very Low Very Low
Metabolic Disorder 6 5.00 Very Low Very Low Very Low
Hypertrophy 3 5.00 Very Low Very Low Very Low
Subacute Sclerosing Panencephalitis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several groups have used microarray data to examine the expression changes when a single miRNA changes, and we used the mean absolute expression approach described recently by Arora and Simpson [49] and also the tissue-centric approach described by Sood et al. [50] to determine whether we could detect shifts in the average expression of mRNA targets of the muscle-specific miRNAs (miR-1, miR-133a/b and miR-206, collectively known as 'myomirs') in human skeletal muscle.
Regulation (targets) of miR-206 in muscle
1) Confidence 0.08 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0 Pain Relevance 0
CDC42 and PTBP1 were selected for study because they ranked highly as targets of miR-133/miR-206 in the TargetScan database and both proteins are relevant for muscle cell differentiation and metabolism [57,58].
Regulation (targets) of miR-206 in muscle cell
2) Confidence 0.08 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0 Pain Relevance 0
Interestingly, reduction in miR-133a using an antagomir (Figure S4A in Additional file 1) had an indirect effect on the other myomirs, such that miR-133b (expected due to sequence similarity) and miR-206 (unexpected) were substantially reduced.
Regulation (effect) of miR-206
3) Confidence 0.08 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0 Pain Relevance 0

General Comments

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