INT30438

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Context Info
Confidence 0.57
First Reported 1985
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 1.15
Pain Relevance 10.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdyn)
Anatomy Link Frequency
nucleus accumbens 4
paw 2
brains 2
pituitary 2
frontal cortex 2
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 63 100.00 Very High Very High Very High
Enkephalin 56 100.00 Very High Very High Very High
Nucleus accumbens 20 99.84 Very High Very High Very High
Opioid 261 99.72 Very High Very High Very High
Dopamine 6 99.64 Very High Very High Very High
Antinociceptive 23 99.56 Very High Very High Very High
Morphine 48 99.30 Very High Very High Very High
Paracetamol 11 98.80 Very High Very High Very High
opiate 2 98.52 Very High Very High Very High
addiction 3 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 1 100.00 Very High Very High Very High
Opiate Addiction 1 98.52 Very High Very High Very High
Urological Neuroanatomy 12 97.36 Very High Very High Very High
Targeted Disruption 9 96.16 Very High Very High Very High
Drug Dependence 1 86.88 High High
Nociception 19 81.48 Quite High
Depression 2 79.52 Quite High
INFLAMMATION 140 72.64 Quite High
Pain 74 50.00 Quite Low
Stress 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, mCREB expression was colocalized with and decreased the expression of prodynorphin in nucleus accumbens medium spiny neurons, and antagonism of dynorphin in the nucleus accumbens was sufficient to produce an antidepressant-like effect similar to that observed after blockade of CREB.
Negative_regulation (decreased) of Gene_expression (expression) of prodynorphin in nucleus accumbens associated with nucleus accumbens, antidepressant and dynorphin
1) Confidence 0.57 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12486182 Disease Relevance 0.33 Pain Relevance 0.63
Together, these experiments demonstrated that DeltaFosB in the NAc, partly through the repression of dynorphin expression, mediates several major features of opiate addiction.
Negative_regulation (repression) of Gene_expression (expression) of dynorphin in NAc associated with addiction, nucleus accumbens, dynorphin, repression and opiate
2) Confidence 0.45 Published 2006 Journal Nat. Neurosci. Section Abstract Doc Link 16415864 Disease Relevance 0.29 Pain Relevance 1.23
The processing profiles of Dyn peptides extracted from brains of these mice reveal a complete lack of Dyn A-8 and a substantial reduction in the levels of Dyn A-17 and Dyn B-13.
Negative_regulation (reduction) of Gene_expression (levels) of Dyn in brains associated with dynorphin
3) Confidence 0.33 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987860 Disease Relevance 0 Pain Relevance 0.53
In neonatal 6-OHDA-lesioned animals, the category with 95% or more DA loss exhibited a reduction in the levels of DYN in the postnatal period whereas the category with less than 95% DA loss did not show significant changes in DYN levels.
Negative_regulation (reduction) of Gene_expression (levels) of DYN associated with dopamine
4) Confidence 0.31 Published 1996 Journal Neuropeptides Section Abstract Doc Link 8868307 Disease Relevance 0 Pain Relevance 0.43
Our present results demonstrate that the combination of inactive doses of PARA (100 mg/kg) and morphine (3 mg/kg) is just as effective in decreasing the levels of DYN A as full antinociceptive doses of PARA or morphine alone in the frontal cortex of the rat.
Negative_regulation (decreasing) of Gene_expression (levels) of DYN in frontal cortex associated with paracetamol, dynorphin, urological neuroanatomy, antinociceptive and morphine
5) Confidence 0.26 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11331077 Disease Relevance 0.27 Pain Relevance 2.16
When administered i.t. 5 min before the injection of 0.5% formalin solution into the dorsal surface of a hindpaw, dynorphin A (0.5-2 nmol) and dynorphin B (2-8 nmol) produced a dose-dependent and significant reduction of the paw-licking response.
Negative_regulation (reduction) of Gene_expression (produced) of dynorphin B in paw associated with dynorphin
6) Confidence 0.07 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8957219 Disease Relevance 0 Pain Relevance 0.71
Although DYN and PDYN levels were generally reported to be low, this opioid peptide is likely to be of some significance in mediating peripheral antinociception as antiDYN has been reported to inhibit IL-1?
Negative_regulation (reported) of Gene_expression (levels) of DYN associated with antinociception, dynorphin and opioid
7) Confidence 0.05 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.13 Pain Relevance 1.69
Although DYN and PDYN levels were generally reported to be low, this opioid peptide is likely to be of some significance in mediating peripheral antinociception as antiDYN has been reported to inhibit IL-1?
Negative_regulation (low) of Gene_expression (levels) of DYN associated with antinociception, dynorphin and opioid
8) Confidence 0.05 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.13 Pain Relevance 1.69
Acute administration of 150 micrograms NE + 10 micrograms EE2 decreased the levels of methionine-enkephalin (ME), leucine-enkephalin (LE), dynorphin (DYN) and beta-endorphin like immunoreactivity (beta-EI) by about 50% in the pituitary.
Negative_regulation (decreased) of Gene_expression (levels) of DYN in pituitary associated with dynorphin and enkephalin
9) Confidence 0.04 Published 1985 Journal Peptides Section Abstract Doc Link 2866495 Disease Relevance 0 Pain Relevance 1.38

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