INT304382

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.77
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRS1) signal transduction (IRS1) plasma membrane (IRS1)
nucleus (IRS1) cytoplasm (IRS1) signal transducer activity (IRS1)
Anatomy Link Frequency
muscle 2
IRS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 13 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 35 98.34 Very High Very High Very High
Disease 17 82.48 Quite High
Diabetes Mellitus 79 82.16 Quite High
Impaired Glucose Tolerance 13 5.00 Very Low Very Low Very Low
Obesity 7 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Hyperinsulinism 2 5.00 Very Low Very Low Very Low
Metabolic Disorder 2 5.00 Very Low Very Low Very Low
Hypertrophy 1 5.00 Very Low Very Low Very Low
Subacute Sclerosing Panencephalitis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
signaling, is extensively implicated in all aspects of skeletal muscle function [61], while at an individual gene level, the directional changes in ERK1/2 and MEK1/2 are consistent with the emerging mechanism through which saturated fatty acids induce muscle insulin resistance [62] and with decreased IRS-1 (insulin receptor substrate-1) phosphorylation [63] promoting the degradation of IRS-1 [64] and thus impaired insulin action.
Positive_regulation (promoting) of Protein_catabolism (degradation) of IRS-1 in muscle associated with insulin resistance
1) Confidence 0.16 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.77 Pain Relevance 0

General Comments

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