INT304385

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.80
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRS1) signal transduction (IRS1) plasma membrane (IRS1)
nucleus (IRS1) cytoplasm (IRS1) signal transducer activity (IRS1)
Anatomy Link Frequency
muscle 1
IRS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 72.36 Quite High
Inflammation 6 62.24 Quite High
tolerance 14 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 44 98.06 Very High Very High Very High
Metabolic Syndrome 52 85.40 High High
Disease 21 81.92 Quite High
Diabetes Mellitus 89 81.60 Quite High
Obesity 9 69.08 Quite High
Cardiovascular Disease 6 64.96 Quite High
INFLAMMATION 6 62.24 Quite High
Increased Venous Pressure Under Development 3 57.36 Quite High
Coronary Artery Disease 1 50.56 Quite High
Vasculitis 1 7.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we probably observed the amount of p-serine-636/639-IRS-1 in the cell after its degradation.
Protein_catabolism (degradation) of 639-IRS-1
1) Confidence 0.42 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 1.04 Pain Relevance 0.10
signaling, is extensively implicated in all aspects of skeletal muscle function [61], while at an individual gene level, the directional changes in ERK1/2 and MEK1/2 are consistent with the emerging mechanism through which saturated fatty acids induce muscle insulin resistance [62] and with decreased IRS-1 (insulin receptor substrate-1) phosphorylation [63] promoting the degradation of IRS-1 [64] and thus impaired insulin action.
Protein_catabolism (degradation) of IRS-1 in muscle associated with insulin resistance
2) Confidence 0.34 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.76 Pain Relevance 0

General Comments

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